C-jun gene

Heterdimers of the Jun and Fos transcription factor family constitute the transcription factor AP-1. Oxidative stress results in the increased transcription of the c-fos and c-jun genes although only a moderate induction of AP-1 occurs. 

Recently, it has been demonstrated that mechanical stress rapidly induced phosphorylation of PDGF receptor, activation of integrin receptor, stretch-activation of cation channels, and production of G proteins. Once mechanical stress was sensed, protein kinase C and MAPKs were activated, leading to increased c-fos and c-Jun gene expression and enhanced transcription factor AP-1 DNA binding activity. The application of physical forces also rapidly resulted in expression of MAPK phosphatase-1 (MKP-1), which inactivates MAPKs. 

The c-jun gene is rapidly induced by a great variety of signals, ranging from growth factors and cytokines to lipid messengers and G proteins. >5 Each signal may result in a... 

Munoz, E., Zubiaga, A.M. and Huber, B.T. (1992). Interleukin-1 induces c-fos and c-jun gene expression in T helper type II cells through different signal transmission pathways. Eur. J. Immunol. 22, 2101-2106. 

Crocidolite, chrysotile Rat pleural meso-thelial cells hamster tracheal epithelial cells c-fos and c-jun mRNA In contrast to phorbol 12-myristate 13-acetate, which induced rapid and transient increases in c-fos and c-jun mRNA, asbestos caused 2-to 5-fold increases in c-fos and c-jun mRNA that persisted for at least 24 h in mesothelial cells. These inductions were dose-dependent and were most pronounced with crocidolite. Induction of c-jun gene expression by asbestos occurred in tracheal epithelial cells but was not accompanied by a corresonding induction of c-fos gene expression. In both cell types, asbestos induced increases in protein factors specifically binding to DNA sites that mediate gene expression by the AP-1 family of transcription factors. Heintz et al. (1993)... 

Devary Y, Gottlieb RA, Lau LF, Karin M (1991) Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol 11 2804-2811... 

Radjendirane V, Jaiswal AK Coordinated induction of the c-jun gene with genes encoding quinone oxidoreductases in response to xenobiotics and antioxidants. 

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