Butyl propyl amine

Figure 19-9 shows the mass spectrum of butyl propyl amine. The base peak (m/z 72) corresponds to a cleavage with loss of a propyl radical to give a resonance-stabilized iminium ion. A similar a cleavage, with loss of an ethyl radical, gives the peak at m/z 86. 

Mass spectrum of butyl propyl amine (N-propylbutan- 1-amine). Note the odd mass number of the molecular ion and the even mass numbers of most fragments. The base peak corresponds to a cleavage in the butyl group, giving a propyl radical and a resonance-stabilized iminium ion. 

The amines are a group of compounds with the general formula R-NHj, and all the common amines are hazardous. As a class the amines pose more than one hazard, being flammable, toxic, and, in some cases, corrosive. The amines are an analogous series of compounds and follow the naming pattern of the alkyl halides and the alcohols that is, the simplest amine is methyl amine, with the molecular formula of CH NHj. Methyl amine is a colorless gas with an ammonia-like odor and an ignition temperature of 806°F. It is a tissue irritant and toxic, and it is used as an intermediate in the manufacture of many chemicals. Ethyl amine is next in the series, followed by propyl amine, isopropyl amine, butyl amine and its isomers, and so on. 

Inward Rectifier K+ Channels. Figure 6 Spermine (Amino-propyl-amino-butyl-amino-propyl amine) is a long linear naturally occurring polyamine containing four nearly equally spaced positively charged (at normal pH) amines. Although 16 A long, the molecule is only about 3 A wide, similar to a dehydrated potassium ion. 

Ethyl amine is next in the series, followed by propyl amine, isopropyl amine, butyl amine and its... 

Aryl-1,5-di-tert.-butyl-6-oxo-2,4-cyclohexadieny lperoxy)- bis-[3-(2-oxy-benzyliden-amino)-propyl]-amin - EI3/1, 208 (Peroxygenierung)... 

Preparation of imines and enamines from carbonyl compounds and amines can be achieved with a dehydrating agent under acid/base catalysis [563]. Basically, primary amines afford imines unless isomerization to an enamine is favored as a result of conjugation, etc (see Eq. 252), and secondary amines afford iminium salts or enamines. These transformations can be conducted efficiently with a catalytic or stoichiometric amount of a titanium salt such as TiCU or Ti(0-/-Pr)4. Equation (247) illustrates an advantageous feature of this method in the imination of a hindered ketone. f-Butyl propyl ketone resisted the formation of the imine even by some methods reported useful for sterically hindered ketones [564,565]. The TiCU-based method works well, however, for this compound, giving the desired imine in high yield within a relatively short reaction period [566]. Imine derivatives such as iV-sulfonylimines could be... 

Similar observations have been reported for the oxidation of aliphatic hydroxylamines, where di-ethyl, di-n-propyl, and di-rc-butyl hydroxyl-amine have been found to react with relative rates equal to 1 5.3 3.4 [72]. The reaction may be represented by... 

Amines, prim., Alkylamines Methyl-, Ethyl-, Propyl-, Butyl-, Benzyl-amine Hexamethylenediamine Dimethyl-, Diethyl-, Diisopropyl-, DibutyU, Dicyclohexyl-amine, Morpholine Amines, tert. Trialkyl-amines... 

C11H25N butyl-(l-isopropyl-2-methyl-propyl)-amine 54562-08-2... 

The above is a general procedure for preparing trialkyl orthophosphates. Similar yields are obtained for trimethyl phosphate, b.p. 62°/5 mm. triethyl phosphate, b.p. 75-5°/5 mm. tri-n-propyl phosphate, b.p. 107-5°/5 mm. tri-Mo-propyl phosphate, b.p. 83-5°/5 mm. tri-wo-butyl phosphate, b.p. 117°/5-5 mm. and tri- -amyl phosphate, b.p. 167-5°/5 mm. The alkyl phosphates are excellent alkylating agents for primary aromatic amines (see Section IV,41) they can also be ua for alkylating phenols (compare Sections IV,104-105). Trimethyl phosphate also finds application as a methylating agent for aliphatie alcohols (compare Section 111,58). 

By reaction of 2-alkyl-4,6-dichloro-l,3,5-trimethylborazines (alkyl = methyl, ethyl, i-propyl) with bis(trimethylsilyl)amine the tetrameric borazine ring systems 4-6 are produced (Fig. 2) they can be purified by several successive vacuum sublimations (yields 4-60%). If the borazines carry n-propyl and tert-butyl groups in the 2-position or if methylbis(trimethylsilyl)amine is used to bridge the borazine molecules, the macrocyclic ring formation is inhibited [17, 18]. 

Mikolajczyk and coworkers have summarized other methods which lead to the desired sulfmate esters These are asymmetric oxidation of sulfenamides, kinetic resolution of racemic sulfmates in transesterification with chiral alcohols, kinetic resolution of racemic sulfinates upon treatment with chiral Grignard reagents, optical resolution via cyclodextrin complexes, and esterification of sulfinyl chlorides with chiral alcohols in the presence of optically active amines. None of these methods is very satisfactory since the esters produced are of low enantiomeric purity. However, the reaction of dialkyl sulfites (33) with t-butylmagnesium chloride in the presence of quinine gave the corresponding methyl, ethyl, n-propyl, isopropyl and n-butyl 2,2-dimethylpropane-l-yl sulfinates (34) of 43 to 73% enantiomeric purity in 50 to 84% yield. This made available sulfinate esters for the synthesis of t-butyl sulfoxides (35). 

Notes on the preparation of secondary alkylarylamines. The preparation of -propyl-, ijopropyl- and -butyl-anilines can be conveniently carried out by heating the alkyl bromide with an excess (2-5-4mols) of aniline for 6-12 hours. The tendency for the alkyl halide to yield the corresponding tertiary amine is thus repressed and the product consists almost entirely of the secondary amine and the excess of primary amine combined with the hydrogen bromide liberated in the reaction. The separation of the primary and secondary amines is easily accomplished by the addition of an excess of per cent, zinc chloride solution aniline and its homologues form sparingly soluble additive compounds of the type B ZnCl whereas the alkylanilines do not react with sine chloride in the presence of water. The excess of primary amine can be readily recovered by decomposing the zincichloride with sodium hydroxide solution followed by steam distillation or solvent extraction. The yield of secondary amine is about 70 per cent, of the theoretical. 

Substitution of groups other than i-propyl or t-butyl on nitrogen also leads to active compounds. Primary amine 122 is reacted with p-(p-chloroethoxy)-benzamide (123) to give the p-blocker, tolamolol (124).60... 

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