Buccastem tablets

Buccastem tablets are a form of prochlorperazine for buccal administration, containing 3 mg of prochlorperazine in a polysaccharide base. When placed in position the tablet softens over a period of a few minutes to form a gel which adheres to the gum and gradually releases the dmg. 

Q82 Buccastem consists of prochlorperazine, a phenothiazine derivative, v/hich is presented as tablets that are to be placed high betv/een the upper lip and gum and allov/ed to dissolve there. It may be used in the treatment of nausea and vomiting associated v/ith migraine, as absorption from the stomach, v/hich is usually delayed in migraine, is avoided. 

Examples of marketed mucoadhesive formulations are Attach buccal tablets (triamcinolone acetonide), Susadrin sublingual tablets (nitroglycerin Forest Laboratories, NY), and Buccastem buccal tablets (prochlorperazine maleate Reckitt and Colman, England). 

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