Buccastem

Q82 Buccastem consists of prochlorperazine, a phenothiazine derivative, v/hich is presented as tablets that are to be placed high betv/een the upper lip and gum and allov/ed to dissolve there. It may be used in the treatment of nausea and vomiting associated v/ith migraine, as absorption from the stomach, v/hich is usually delayed in migraine, is avoided. 

Buccastem tablets are a form of prochlorperazine for buccal administration, containing 3 mg of prochlorperazine in a polysaccharide base. When placed in position the tablet softens over a period of a few minutes to form a gel which adheres to the gum and gradually releases the dmg. 

Figure 7.2 Mean plasma levels of prochlorperazine versus time in 12 volunteers for the buccal (Buccastem) or oral (Stemetil) delivery of prochlorperazine...

Examples of marketed mucoadhesive formulations are Attach buccal tablets (triamcinolone acetonide), Susadrin sublingual tablets (nitroglycerin Forest Laboratories, NY), and Buccastem buccal tablets (prochlorperazine maleate Reckitt and Colman, England). 

Buccastem" prochlorperazine, bucillamine [inn, jan] (de oi9 sa 96) is a mercaptocysteine derivative, a penicillamine derivative. It is a CHELATING AGENT that can be used as an ANTIINFLAMMATORY in antirheumatic therapy. 

Dimaleate, t 3NH l2< 3 N308S. Buccastem, Compazine, Erne-find, Nibromin A, Slernetii, Vertigoa. Minute crystals, mp 228. Very slightly sol in water (less than 0.1% at 20 ). Slightly sol in methanol, ethanol. Practically insol in ether. 

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