Broussonetia zeylanica

Broussonetia zeylanica (Thwait.) Comer is endemic to Sri Lanka and its tough bark-fibers were used to make string [15]. 

Only three constituents have been reported from Broussonetia zeylanica, all by a group at the University of Peradeniya in Sri Lanka [89-91]. A major alkaloid, 8-hydroxyquinoline-4-carbaldehyde (55), was identified as an antimicrobial agent active against Staphyllococus aureus and Candida albicans (the levels of activity were not specified) [89] and then two minor compounds, 3,4 -dihydroxy-2,3 -bipyridine (56) and 3,4-bis(8-hydroxyquinolin-4-yl)-y-butyrolactone (broussonetine, 57), were reported, Fig. (10) [90,91]. However, the structure of 3,4 -dihydroxy-2,3 -bipyridine (56) was revised to 8-hydroxyquinoline-4-carbaldehyde oxime (58) by synthesis [92,93]. Also, it was noted that an artefactual origin of this oxime (58) could not be ruled out due to the presence of the corresponding aldehyde (55) [93]. 

Broussonetia zeylanica (Thw.) Comer6 (= Allaeanthus zeylanicus Thw. Ficus hispidus L. f. 

A series of simple, new 8-hydroxyquinoline (oxine) alkaloids was isolated from the timber of Broussonetia zeylanica Thw., an endemic plant of the family Moraceae. Fractionation led to the isolation of the major alkaloidal constituent, 8-hydroxyquinoline-4-carbaldehyde (1) CioH7N02, mp 155-156°C, in 0.25% yield from the dried timber (15). The structure of 1 was established with the aid of spectroscopic data and chemical derivatization... 

Although the endemic species Broussonetia zeylanica (Thw.) has no claims of medicinal applications, when screened, some of its extracts exhibited significant antimicrobial activity against three common pathogenic organisms, Candida albicans, Escherichia coli, and Staphylococcus aureus (15). Bioactivity-guided fractionation led to the isolation of the major antimicrobial alkaloid, 8-hydroxyquinoline-4-carbaldehyde (1), active against C. albicans and S. aureus (17,18). 8-Hydroxyquinoline (oxine) and its derivatives are known to have an array of antimicrobial properties, and a number... 

Broussonetia zeylanica Broussonetia zeylanica Alstonia macrophylla Tabemaemontana dichotoma Alstonia macrophylla Tabemaemontana dichotoma Tabemaemontana dichotoma Limonia acidissima Neolitsea fuscata Neisosperma oppositifolia Holarrhena mitis Hunteria zeylanica Hunteria zeylanica Tabemaemontana dichotoma Mitragyna parvifolia Uncaria elliptica Neisosperma oppositifolia Tabemaemontana divaricata Tabemaemontana divaricata Tabemaemontana dichotoma Tabemaemontana dichotoma Murraya koenigii Murraya koenigii... 

Broussonetia zeylanica Choisya ternata Dictamnus angustifolius... 

A new alkaloid, 4-formyl-8-hydroxyquinoline, was isolated from Broussonetia zeylanica the structure was apparent from spectral studies and by its Wolff-Kishner reduction to 8-hydroxy-4-methylquinoline. 6-Hydroxykynurenic acid was obtained from Limonium species " this is the first time that the compound has been isolated from members of the Plumbaginaceae. A new synthesis of echinopsine has been carried out (Scheme 2). ... 

Alkaloid from the timber of Broussonetia zeylanica (Moraceae). Deep-yellow cryst. (CHCI3). Mp 171-173°, Mp 223-224°. Struct, of the nat. prod, in doubt authentic synthetic material (Mp 171-173°) is not identical with the alkaloid assigned this struct. 

Quinoline-4-carbaldehyde derivatives also occur in higher plants (Table Vlll). For example, 8-hydroxyquinoline-4-carbaldehyde oxime (J.3.1 Scheme 9) was isolated from Broussonetia zeylanica (Moraceae) (151-153). (+)-Tuberosine B (J.1.2), an unprecedented tetrahydroquinoline alkaloid, has been reported in the inaccessible Chinese literature as a new metabolite of Allium tuberosum (Alliaceae) (157). Eichhornia crassipes (Pontederiaceae) is an invasive plant and often jams rivers and lakes with uncounted thousands of tons of floating plant matter. It has yielded 1,4-dimethylquinolinium iodide (J.4) (142). 

The genus Broussonetia L Her. ex Vent, of the Moraceae (mulberry family) is represented by lactiferous trees or shrubs. Broussonetia comprises about 30 species and is distributed throughout various regions of the world including Africa, East Asia, and North America [1,2]. Thus far, only three species of the genus Broussonetia have been studied for their secondary metabolites, namely, B. kazinoki, B. papyrifera, and B. zeylanica. 

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