Tabemaemontana divaricata

VAN DER DEUDEN, R., THRELFALL, D.R., VERPOORTE, R WHITEHEAD, I.M., Regulation and enzymology of pentacyclic triterpenoid phytoalexin biosynthesis in cell suspension cultures of Tabemaemontana divaricata, Phytochemistry, 1989, 28, 2981-2988. 

Eburn amine Tabemaemontana divaricata Rhazya stricta... 

STEVENS, L.H., BLOM, T.J.M., VERPOORTE, R., Subcellular localization of tryptophan decarboxylase, strictosidine synthase and strictosidine glucosidase in suspension cultured cells of Catharanthus roseus and Tabemaemontana divaricata. Plant Cell Rep., 1993,12, 563-576. 

In a paper published in 1991, Arambewela and Ranatunge describe the isolation of several indole alkaloids from Tabemaemontana divaricata (199). For one of them they presented structure 96 and called it 11-methoxy-Va-methyldihydropericyclivine, although this structure represents 11-methoxy-Na-methyldihydro-16-epipericyclivine (Fig. 6). Very few data were presented in support of the proposed structure 96 or its 16-epimer 97. In particular, the H NMR data S 2.43 (3H, s) and S 2.54 (3H, s) given for )N—CH3 and — COOCH3, respectively, do not support either of the epimerie structures. In the writers opinion, the claims concerning the presence of ll-methoxy-iVa-methyldihydro-16-epipericyclivine (96) or 11-methoxy-JVa-methyldihydropericyclivine (97) in T. divaricata must be considered premature. 

Broussonetia zeylanica Broussonetia zeylanica Alstonia macrophylla Tabemaemontana dichotoma Alstonia macrophylla Tabemaemontana dichotoma Tabemaemontana dichotoma Limonia acidissima Neolitsea fuscata Neisosperma oppositifolia Holarrhena mitis Hunteria zeylanica Hunteria zeylanica Tabemaemontana dichotoma Mitragyna parvifolia Uncaria elliptica Neisosperma oppositifolia Tabemaemontana divaricata Tabemaemontana divaricata Tabemaemontana dichotoma Tabemaemontana dichotoma Murraya koenigii Murraya koenigii... 

Tabemaemontana divaricata R. Br.-372 Tabemaemontana heterophyUa Vahl—372 Tabemaemontana muricata Link ex Roe-mer et Schultes-372,401 Tabemaemontana pandacaqui PoLret—372 Tabemaemontana sananho Ruiz et Ravon— 372,401,416... 

Prenyltransferase activities have been studied in C. roseus both at the enzyme level and at the product level. Biosynthetic capabilities were investigated by incubating [1- C]IPP with aliquots of cell-free homogenates prepared from P. aphanidermatum treated and untreated suspension-cultured cells of C. roseus. After elicitation, the total incorporation of IPP into prenyl lipids was decreased, in particular into squalene. But the incorporation of IPP into some (as yet unidentified) compounds was increased (99). The prenyltransferases and subsequent enzyme activities are relatively easily extracted and remain complexed so that the product of one enzyme can be used as a substrate for the next enzyme. With an assay for these enzymes as described in detail in Threlfall and Whitehead (101), about a dozen enzyme activities could be detected in series using cell-free preparations of elicited Tabemaemontana divaricata cells (27). In the elicited C. roseus cells, the activities of IPP isomerase, famesyl diphosphate synthase, squalene synthase, squalene-2,3-epoxidase (and probably also a squalene-2,3-epoxide cyclase) were thus detected. Compared with the control nontreated cells, squalene production seemed to be reduced particularly (99). 

Mukhram MA, Shivakumar H, Viswanatha GL, Rajesh S. Anti-fertility effect of flower extracts of Tabemaemontana divaricata in rats. Chin J Nat Med 2012 10(l) 58-62. 

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