Hunteria zeylanica

Pathama L, Michihisa T, Kinzo M, et al. Inhibitory effects of corymine, an alkaloidal component from the leaves of Hunteria zeylanica, on glycine receptors expressed in Xenopus oocytes. Euro J Pharmacol 1997 332 321-326. [Pg.161]

Normal Series. Among yohimbines with a normal skeleton, there are three alkaloids in which the methoxycarbonyl substituent at C-16 is lacking, namely, yohimbol (72), its A/b-methochloride, and the recently discovered 17-epiyohim-bol (73) isolated from Hunteria zeylanica (67). [Pg.158]

Fig. 64. Hunteria zeylanica (Retz.) Gardn. Thw. From KLU 1658. Field collector 4/17/1970, E. Soepadmo. Geographical localization Sempam River, Raub, Pahang, altitude 2000 feet, Malaysia. Botanical identification Margraf, 1973.

Corymine Hunteria zeylanica (Apocynaceae) [GABAA-R antagonist... [Pg.104]

Deformylcorymine Hunteria zeylanica (Apocynaceae) GABAA-R (current... [Pg.104]

Deformylcorymine Hunteria zeylanica (Apocynaceae) channel blocker) (11) [CNS stimulant, potentiates convulsions by Strychnine Picrotoxin] Gly-R antagonist (non-... [Pg.116]

Tuboxenine (144) has been shown to occur in the leaves and bark of Hunteria zeylanica Gardn. (153), and N-methyl-14,15-didehydrotuboxenine... [Pg.41]

Hydroxy-17-decarbomethoxy-16-dihydro-epiajmalicine (87), Q9H24N2O2, mp 185°C, is a new natural product encountered in the bark of Hunteria zeylanica, a plant endemic to Sri Lanka (78). Structural proof involved the semisynthesis of 87 by oxymercuration of corynantheal. Other indole alkaloids belonging to this class isolated from H. zeylanica included yohim-bol (88) and the new natural product epiyohimbol (89), C19H24N2O, mp 257°C, whose structures were confirmed by comparison with NaBfL reduction products of yohimbone. The fruits of Alstonia macrophylla have... [Pg.49]

Hunteria zeylanica has afforded several alkaloids of the eburnamine group (79). These included four previously known alkaloids, ebur-namine (113), isoeburnamine (114), O-methylebumamine (115), and... [Pg.55]

A pentacyclic indole alkaloid isolated from the leaves of Hunteria zeylanica was identified as pleiocarpamine (167) by Arambewela and Khuong-Huu (78). [Pg.70]

Hydroxy-17-decarbomethoxy-16-dihydro- Indole Hunteria zeylanica Bk 78... [Pg.90]

Broussonetia zeylanica Broussonetia zeylanica Alstonia macrophylla Tabemaemontana dichotoma Alstonia macrophylla Tabemaemontana dichotoma Tabemaemontana dichotoma Limonia acidissima Neolitsea fuscata Neisosperma oppositifolia Holarrhena mitis Hunteria zeylanica Hunteria zeylanica Tabemaemontana dichotoma Mitragyna parvifolia Uncaria elliptica Neisosperma oppositifolia Tabemaemontana divaricata Tabemaemontana divaricata Tabemaemontana dichotoma Tabemaemontana dichotoma Murraya koenigii Murraya koenigii... [Pg.404]

Hunteria zeylanica, and from the leaves of Peschiera echinata. [Pg.240]

Nugroho AE, Hirasawa Y, Kawahara N, Goda Y, Awang K, Hadi AHA, Morita H (2009) Bisnicalaterine A, a vobasine-vobasine bisindole alkaloid from Hunteria zeylanica. J Nat Prod 72 1502-1506... [Pg.476]

Bisnicalaterine A (45), consisting of two vobasine-type units, was isolated from the leaves of Hunteria zeylanica (Apocynaceae), together with two... [Pg.268]

Bisnicalaterines B (142) and C (143) were isolated from the bark of Hunteria zeylanica (Apocynaceae) (Figure 23). Both compounds consisted of the same ebuman and Corynanthe units that were connected via C-16 in the ebuman unit and C-9 in the Corynanthe unit. Their stmctures including their absolute configurations were established by NMR, CD, and computational methods. Bisnicalaterines B (142) and C (143) were a pair of atro-pisomers and showed potent vasorelaxant activity on isolated rat aorta. [Pg.290]

Ceridimine (303), from Pagiantha cerifera was the first example of a qua-sidimeric-type alkaloid in which the additional tryptamine unit has a free side chain and is linked by its aromatic moiety to the monoterpenoid indole unit 203). The primary amine function was readily acetylated and methylated, and its partial synthesis via coupling of vobasinol with tryptamine confirmed the structure assignment. Demethylceridimine (304) was later obtained from P. buchtieni T. buchtieni), which also provided another quasidimer, buchtienine (254) vide supra) 153). The third member of this group, hunteriatryptamine (305), was obtained from Hunteria zeylanica from Thailand. It differs from the previous two alkaloids by the presence of a hydroxymethyl function on the vobasinyl C(16) in place of H 204). [Pg.228]

Two new indole alkaloids, bisnicalaterine D (1), consisting of an ebumane and a corynanthe type of skeletons, and nicalaterine A (2) were isolated from the bark of Hunteria zeylanica. Their structures were elucidated by various spectroscopic data such as NMR and CD spectra. A series of bisnicalaterines and nicalaterine A showed potent anti-plasmodial activity against P. falciparum 3D7 [28]. [Pg.457]

Nugroho AE, Sugai M, Hirasawa Y, Hosoya T, Awang K, Hadi AH, Ekasari W, Widyawaruyanti A, Morita H (2011) New antiplasmodial indole alkaloids from Hunteria zeylanica. Bioorg Med Chem Lett 21(11) 3417-3419... [Pg.460]

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