Bromocriptine Alcohol

Bromocriptine Alcohol Bromocriptine is an ergot alkaloid and a dopamine receptor D2 agonist that inhibits prolactin release from the pituitary gland [228]. Bromocriptine is typically used to treat Parkinsonian syndrome as well as hyperprolactinaemia, growth hormone- and prolactin-related disorders such as menstrual disorders, infertility, and hypogonadism. 

Transformation of bromocriptine free base 2 into water soluble salt -mesylate, is the only way to obtain a suitable therapeutical form. Crystallization of mesylate using alcohol as a solvent in the presence of excess of strong acid, e.g. methanesulphonic acid can induce formation of 12 -0-alkyl-derivative 2. Until now this derivatisation of ergot molecule has been practically unknown. In continuation we developed the preparative method for obtaining these compounds, (using tetrafluoroboric acid as a catalyst) (ref. 20). 

Bromocriptine 2 (0.65 g, 1 mmol) was dissolved in 100 ml of dry ethanol and 60 ml of tetrafluoroboric acid / diethylether complex (85 %) was added while stirring. After standing overnight at RT the solvent was evaporated and the raw product isolated by extraction in the system dichloromethane 12% ammonia in water and evaporated to the dry residue. This residue was applied to the chromatographic column (I.D. = 2 cm, lenght = 20 cm) packed with silicagel and eluted with dichloromethane / ethylacetate =1 1. The fractions containing 2 were evaporated to the dry residue and crystallized from alcohol. 

Bromocriptine follows the behaviour sketched above and is thus rather labile in aqueous or aqueous/alcoholic solutions, particularly in the presence of acid, yielding mainly the equilibrated mixture with its 8-epimer (1) and to a smaller extent, its hydrolysis products 2-bromo-lysergamide and 2-bromo-lysergic acid and their 8a-isomers, respectively. 

Lawford, Bruce R., Ross M. Young, John Rowell, Joan Qualichefski, Barbara H. Fletcher, Karl Syndulko, Terry Ritchie, and Ernest P. Noble. 1995. "Bromocriptine in the Treatment of Alcoholics with the D2 Dopamine Receptor A1 Allele." Nature Medicine 1 337-41. 

Engleman EA, McBride WJ, Li TK, Lumeng L, Murphy JM (2003) Ethanol drinking experience attenuates (—)sulpiride-induced increases in extracellular dopamine levels in the nucleus ac-cumbens of alcohol-preferring (P) rats. Alcohol Clin Exp Res 27 424-31 Ennis C, Kemp JD, Cox B (1981) Characterisation of inhibitory 5-hydroxytryptamine receptors that modulate dopamine release in the striatum. J Neurochem 36 1515-20 Ensinger H, Majewski H, Hedler L, Starke K (1985) Neuronal and postjunctional components in the blood pressure effects of dopamine and bromocriptine in rabbits. J Pharmacol Exp Ther 234 681-90... 

ALCOHOL BROMOCRIPTINE t risk of severe side-effects if alcohol is taken at the same time. (e.g. nausea, stomach pain, dizziness) Uncertain Be aware... 

The Cochrane Library is a relatively new and growing electronic library that provides more than 850 summaries of published literature about pharmaceutical and other interventions to improve health. The Library adds new titles four times a year to its cumulative online and CD versions (the latter, available by subscription, offers more databases). The Library s 2000 Issue 3 contains evidence on dozens of clinical dilemmas, such as antibiotic treatment for traveler s diarrhea, antileukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma, opioid antagonists for alcohol dependence, and bromocriptine versus levodopa in early Parkinson s disease. The Cochrane Library also updates earlier reviews when important new evidence becomes available. Among the newest updates are tacrine for Alzheimer s disease, tricyclic and related drugs for nocturnal enuresis in children, and nicotine replacement therapy for smoking cessation. 

DRD2 Dopamine receptor D2 rs6277, rsl799978, rs6275 Cocaine, alcohol, opioids Acamprosate, bromocriptine, disulfiram, methadone... 

Lawford BR, Young RM, Rowell JA, Qualichefski J, Fletcher BH, Syndulko K, Ritchie T, Noble EP (1995) Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor Al allele. Nat Med 1 337-341... 

There is some very limited evidence to surest that the adverse effects of bromocriptine may possibly be increased by alcohol. 

Ayres J, Ivfeisey MN. Alcohol increases bromocriptine s side effects. NEnglJMed (19SG) 302, 806. 

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