Bromhexine hydrochloride

E. Sumarlik and G. Indrayanto, TLC densitometric determination of bromhexine hydrochloride in pharmaceuticals, and its validation. J. Liq. Chrom. Relat. Technol. 27 (2004) 2047-2056. 

Sane et al. reported the determination of diloxanide furoate in pharmaceuticals by gas chromatography [36]. A sample of powdered tablets equivalent to 250 mg of drug was dissolved in chloroform and diluted to a concentration of 5 mg/mL. A mixture of 2 mL of the sample solution and 1 mL of bromhexine hydrochloride solution (the internal standard) was diluted to 5 mL with chloroform, was used for the analysis. The injection volume was 400 nL, which was analyzed at 265°C on a stainless steel column (3 m x 2 mm) containing 3% OV-13 on Chromosorb W-HP (80-100 mesh). Nitrogen was used as the carrier gas at a flow rate of 50 mL/min, and analyte detection was effected using a dual flame ionization detector. 

Levomethadyl Acetate Hydro- Loperamide Hydrochloride Bromhexine Hydrochloride... 

British Anti-Lewisite, 550 Brobenzoxaldine, 404 Brocadopa, 702 Brocresine, xvii Broflex, 381 Brolene, 529, 933 Bromacil, 79, 82 Bromadal, 434 Bromazepam, 400 Bromazine, 402 Bromdiphenhydramine, 402 Bromhexine, 401 Bromhexine hydrochloride, 401 Bromides, 64... 

Bromhexine hydrochloride (Bisolvan) is a bronchial mucolytic agent and secretagogue that may have a stimulating effect on tear secretion. Oral bromhexine and its derivative ambroxol have equivocal results in clinical trials and are associated with side effects of nausea, sweating, and rashes. 

Tang [16] described an improved method for thin layer chromatographic identification of compound buclizine. Compound buclizine contains mainly buclizine hydrochloride, bromhexine hydrochloride, and promethazine hydrochloride. A 20 ml portion of sample solution was made alkaline with 0.05 M sodium hydroxide (2.5 ml) and extracted with chloroform (5 ml). Standard solution of buclizine hydrochloride, bromhexine, hydrochloride, and promethazine together or separately were similarly prepared. The chloroform solution were spotted on to Silica gel G plates (previously treated with 0.5% sodium hydroxymethylcellu-lose solution and activated at 100 °C for 1 h) with chloroform methanol ... 

Qtaitat, M.A. Zughul, M.B. Badwan, A.A. Bromhexine hydrochloride adsorption by some sohd excipients used in the formulation of tablets. Drug Dev. Ind. Pharm. 1988, 14, 415-429. 

Argekar, A.P. Powar, S.G. Simultaneous determination of salbutamol sulfate and bromhexine hydrochloride in formulations by quantitative thin layer chromatography. J. Planar Chromatogr.-Mod TLC 1998,11, 254-257. 

A few examples belonging to the class of sedative expectorants will now be discussed here. Examples Acetylcysteine Bromhexine hydrochloride Ammonium chloride Prepared Ipecacuanha Liquorice Cocillana Potassium iodide. 

Bromhexine hydrochloride has been reported to alter the structure of bronchial secretion, besides playing the dual role of enhancing the volume and reducing the viscosity of sputum. 

Khan, K. A., And Rhodes, C. T., 1975, Disintegration Properties of Calcium Phosphate Dibasic Dihydrate Tablets , Jo wa/ of Pharmaceutical Sciences, 64, pp 166-168. Kukita,T., Yamaguchi, A. Okamoto, A., and Nemoto, M., 1992, Interaction Between Polyethylene Films and Bromhexine Hydrochloride in Sohd Dosage Form. IV. Prevention of the Sorption by Addition of Magnesium Aluminum Silicate , Chemical Pharmaceutical Bulletin, 40(5), pp 1257-1260. 

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