Bromhexine

Chemical Name S-Amino-G -dibromo-N-cyclohexyl-N-methyl-benzenemethanamine Common Name N-(2-Amino-3 -dibromoben2yl)-N-methyl-cyclohexylamine Structural Formula  

Trade Name Manufacturer Country Year Introdi 

In initial steps, 2-nitrobenzylbromide and cyclohexylmethylamine are reacted and that initial product reacted with hydrazine to give N-(2-aminoben2yl)-N-methyl-cyclohexylamlne. 

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Bromperidol 331 Bromhexine 2 96 Bromindione 2, 210 Bromisoval urn 221 Bromodiphenhydramine U 42 Bromoxanide 2, 94 Bromperidol 7, 331 Broperamole 3, 139 Brompheni ramTne 1, 77 Bucainide 125... 

Cyclohexylmagnesium bromide Perhexiline sulfate Cyclohexylmethylamine Bromhexine... 

Ophthosol -Bromhexine Ophthovitol Stanolone Ophtorenin Bupranolo)... 

Ing.)-comb. with bromhexine Corti Biciron (S K Pharma)-comb. with tramazoline... 

C2oHi(,ClN30ftS2 53483-68-4) see Cefaclor (2-nitrobenzyl)(cyciohexyl)methylamine (C14H20N2O2 80638-08-0) see Bromhexine 4-nitrobenzyl 3-hydroxy-7(/f)-phenyIacetamidocepham-4-carboxylate... 

Note Separate potassium iodide and starch solutions can also be used successively [2], The detection limits for bromureides are 40 to 200 ng substance per chromatogram zone [7, 10]. Bromopride, bromazepam, bromhexine and bromocriptine do not reac [10]. 

Bromisoval (h/ f 15-20) yielded dark brown chromatogram zones on a light brown background. Bromopride, bromazepam, bromhexine, bromocriptine, caryophyllene epoxide and rose oxide did not react. 

A molecular dissection of the alkaloid vasicine (52) ultimately resulted in the expectorant and mucolytic agent bromhexine (54). The synthesis starts with displacement of halogen on 2-nitrobenzyl-bromide (53) by N-methyl cyclohexylamine, followed by Raney nickel and hydrazine reduction of the nitro group. Bromination in acetic acid then affords bromhexine. 

E. Sumarlik and G. Indrayanto, TLC densitometric determination of bromhexine hydrochloride in pharmaceuticals, and its validation. J. Liq. Chrom. Relat. Technol. 27 (2004) 2047-2056. 

It was recently observed that a iplant, Adhatoda vasica, long used in Indian herbal medicine (the source of many therapeutic leads) for the relief of cough and respiratory tract congestion, did appear to reduce the quantity and viscosity of sputum. The plant was studied and its active alkaloid named vasicine. The tricyclic quinazoline structure (XXVIII) was then reduced to fragments and a series of derivatives prepared [350]. From these bromhexine (XXIX, Na 274, Bisolvon)... 

The effect of administration of bromhexine to patients suffering from excessive production of viscous sputum (due to a variety of pulmonary disorders) has now been, studied and reported [354]. It is assumed by the authors that the observed effects were directly due to bromhexine though the possibility of activity via a metabolite seems worthy of study. During the study the viscosity of sputum and its fibrous structure were noted. Within five days of commencement of oral administration of bromhexine the fibrous structure was seen to be... 

Other workers have demonstrated improved lung function (including arterial oxygen level increase [355]) and increased response to bronchodilators [356] after bromhexine. Some evidence of weak activity against tubercle bacillus has appeared [357] this could complicate culture control of anti-tubercular therapy. 

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