Breath analysis for

Breath analysis for TCE has provided a more accurate index of exposure than the measurement of metabolites (trichloroethanol and trichloroacetic acid) in the urine. ... 

Amann A, Smith D (eds) (2005) Breath analysis for medical diagnosis and therapeutic monitoring. World Scientific Publ, New Jersey-London-Singapore, p 536... 

Smith D, Spanel P (2007) The challenge of breath analysis for chnical diagnosis and therapeutic monitoring. Analyst 132(5) 390-396... 

Blake, R.S., Whyte, C., Monks, P.S., Ellis, A.M. Proton transfer reaction time-of-flight mass spectrometry a good prospect for diagnostic breath analysis. In Amann, A., Smith, D. (eds.) Breath analysis for clinical diagnosis and therapeutic monitoring, p. 45. World Scientific, Toh Tuck Link, Singapore (2005)... 

A newer angle is presented in an article by Mitch Jacoby in the March 29,2004, issue of Chemical and Engineering News, a weekly publication of the American Chemical Society. Titled Breath Analysis for Medical Diagnosis, many volatile organic chemicals carried in a person s breath are associated with a particular disease. These chemicals may be present only in extremely minute or picomolar-level concentrations. The challenge is to routinely and accurately analyze and correlate the breath chemistry to the disease. 

FIGURE 8.1 The first step of breath analysis for lung cancer detection. Patient is asked to breath in a double compartment bag. The first part of the breath is removed and the second part is then used for analysis. 

The use of breath analysis for clinical diagnostics is still in its infancy, simply because there is little or no knowledge about the origin and role of the majority of the exhaled metabolites. The concentrations of exhaled species are often so low that the known technical problems associated with common ultra-trace analysis make diagnosis within a reasonable time span next to impossible to date. Laser spectroscopic analysis techniques now offer exciting new opportunities they are currently the only ones that allow for on-line, real-time measurements of exhaled trace gases in breath, with parts per billion sensitivity. 

Amann, A., Smith, D. (Eds) (2005) Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring, World Scientific. 

Janovsky, U., Scholl-Btirgi, S., Karall, D. et al. (2005) Breath gas analysis in patients suffering from propionic acidaemia [Chapter 28]. In Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring (Eds A. Amann, D. Smith), World Scientific, Singapore. 

Short-term non-invasive biomarkers for processes producing long-term lung damage-evaluation of the feasibility of candidate measurement systems. Toxicokinetic models have been developed to determine whether breath analysis of pentane and ethane can be used to estimate chronic lung damage from toxicants. 

Zedeck, Morris S. A Review and Analysis of the Use of the 2100 1 Blood-Breath Ratio for Determination of Blood Alcohol Concentration Scientific and Legal Issues. Expert and Scientific Evidence 3 (1996) 269-294. 

Sensors for Breath Analysis An Advanced Approach to Express Diagnostics and Monitoring of Human Diseases... 

Due to a combination of the modified technique for sensor analysis of composite gas mixture with unique properties of the gas-sensitive point-contact matrix, a complex dynamic of interaction between sensitive matter and volatile compounds of exhaled air has been observed. This interaction is characterized by longer adsorption times. This behavior was not observed in our previous work on breath analysis where fihn samples were used [11]. 

Gelperin A, Johnson ATC (2008) Nanotube-based sensor arrays for clinical breath analysis. J Breath Res 2 037015, 6 pp... 

Breath alcohol analysis for drink-and-driving legislation... 

Cao, W., Duan, Y. Current status of methods and techniques for breath analysis. Crit. Rev. Anal. Chem. 37, 3-13 (2007)... 

Breath-by-breath analysis of gases and volatiles is well known in medicine (1). The experimental techniques used, however, were not very well suited to our needs. For our purpose we needed a simple, reliable inlet system without extensive filtering and pressure reduction, but with a high sensitivity and short response times. 

Statutory laws for driving under the influence of alcohol were originally based on the concentration of ethanol in venous whole blood. Because the collection of blood is invasive and requires intervention by medical personnel, the determination of alcohol in expired air has long been the mainstay of evidential alcohol measurements.There is also growing clinical interest m the determination of breath alcohol at the point-of-care. The fundamental principle for use of breath analysis is that alcohol in capillary alveolar blood rapidly equilibrates with alveolar air in a ratio... 

Harding P. Methods for breath analysis. In Garriott JC, ed. Medicolegal aspects of alcohol. Tucson, AZ Lawyers Judges Publishing Co., 1996 181-217. 

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