Breast Tumor inducing factors

Zhou YD et al (2005) Terpenoid tetrahydroisoquinoline alkaloids emetine, king me. and isocephae-line inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells. J Nat Prod 68(6) 947-950... 

In human breast tumor cell lines, endothelins have been reported to induce CCR7 expression at both mRNA level and protein level through activation of endothelin receptor A (ET-RA) in a hypoxia-inducible factor-la (HIF-la)-dependent manner [40]. The endothelin system includes three small 21-amino acid peptides ligands (ET-1, ET-2, and ET-3), two G-protein-coupled receptors (ET-RA and ET-RB), and two activating peptidases [41]. Increased expression of endothelins and their receptors was found in invasive breast cancer compared to normal breast tissues or benign fibroadenomas [42, 43]. In human primary breast cancer, endothelin expression was correlated with CCR7 expression, both of which were associated with LN metastasis [40]. 

Wilson, J. L., J. Burchell, and M. J. Grimshaw. 2006. Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1. Cancer Res 66 11802-11807. 

Sengupta, K., Baneijee, S., Saxena, N., and Baneijee, S.K., Estradiol-induced vascular endothehal growth factor-A expression in breast tumor cells is biphasic and regulated by estrogen receptor-alpha dependent pathway, Int J. Oncol, 22, 609-614,2003. 

Singh TR, Shankar S, Chen X, Asim M, Srivastava RK. Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/ Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo. Cancer Res. 2003 63(17) 5390-5400. 

Dai, J., Fishback, J.A., Zhou, Y.-D., and Nagle, D.G. (2006) Sodwanone and yardenone triterpenes from a South African species of the marine sponge Axinella inhibit hypoxia-inducible factor-1 (HIF-1) activation in both breast and prostate tumor cells. J. Nat. Prod., 69, 1715-1720. 

This compovind has been recently rediscovered in L nderfeldia sp., Dictyoceratida. Furospongolide inhibits Hypoxia-Inducible Factor 1 (HlF-1) in breast tumor cells (Liu Y. etal., 2008). 

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