Breast cancer melatonin

Rao, G.N., Ney, E., and Herbert, R.A. 2000. Effect of Melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene. Breast Cancer Res. Treat. 64,... 

Environmental magnetic fields (1.2 pT, 60 Hz) significantly reduce the inhibitory action of physiological levels of the hormone melatonin on the growth of human breast cancer cells in vitro. A similar inhibitory effect is... 

Harland JD, Liburdy RP. Environmental magnetic fields inhibit the antiproliferative action of tamoxifen and melatonin in a human breast cancer cell line. Bioelectromagnetics 1997 18(8) 555 62. 

M5250 Melatonin Enhances apoptic death of cancer cells inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action. 

E. Schernhammer and S. Hankinson, Urinary Melatonin Levels and Breast Cancer Risk, Journal of the National Cancer Institute 97 (2005) 1084-1087. 

A good night s sleep may do much more than refresh the psyche. Melatonin is a hormone that acts as an antioxidant that combats the free radicals (see Section 3.6.6) that can cause genetic damage. Cortisol is another hormone that helps regulate the immune systan. The disruption of normal sleep cycles results in less melatonin production and lower cortisol activity. Perhaps that may be one reason that shift workers have higher rates of breast cancer than women who sleep normal hours. Regular sleep may help to battle cancer. 

A possible role of NO on the inhibition by melatonin of human breast cancer growth has also been suggested by Blask and Wilson (1994). Based on the antiproliferative effects of NO on A375 melanoma cells (Maragos et al. 1993), they incubated MCF-7 cells for 5 days with 1 nM melatonin either in the presence or not of hT -monomethyl-L-arginine. In the presence of hT -monomethyl-L-arginine, melatonin lacked its antiproliferative activity. 

Schemhmmer ES, Hankinson SE (2005) Urinary melatonin levels and breast cancer risk. J Natl Cancer Inst 97 1084—1087... 

Schernhammer E, Giobbie-Hurder A, Gantman K, Savoie J, Scheib R, Parker L, et al. A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkers. Cancer Causes Control 2012 23(4) 609-16. 

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