Breast cancer curcumin

Several reports have described the anticancer activity of curcumin in a variety of cancer cell lines. In vitro studies have established the activity for curcumin against breast, gastric, hepatic, pancreatic, colorectal, urinary bladder, kidney, prostate, cervical, ovarian, uterine, lung, oral, thymic, and skin cancers. Besides these cancer types, curcumin has shown in vitro therapeutic efficacy against hematological cancers including leukemia, lymphoma, and multiple myeloma. One of our early studies established that the antiproliferative effect of curcumin in human breast cancer cell lines, including hormone-dependent, hormone-independent,... 

Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, Price JE. 2005. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 11 7490-7498. 

Bachmeier BE, Mohrenz TV, Mirisola V, Schleicher E, Romeo F, Hohneke C, Jochum M, Nerlich AG, Pfeffer U. 2008. Curcumin down-regulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. Carcinogenesis 29 779-789. 

Di GH, Li HC, Shen ZZ, Shao ZM. 2003. [Analysis of anti-proliferation of curcumin on human breast cancer cells and its mechanism]. Zhonghua Yi Xue Za Zhi 83 1764-1768. 

Holy JM. 2002. Curcumin disrupts mitotic spindle structure and induces micronuclea-tion in MCF-7 breast cancer cells. Mutat Res 518 71-84. 

Ramachandran C, Fonseca HB, Jhabvala P, Escalon EA, Melnick SJ. 2002. Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line. Cancer Lett 184 1-6. 

Somasundaram S, Edmund NA, Moore DT, Small GW, Shi YY, Orlowski RZ. 2002. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res 62 3868-3875. 

As mentioned above, experimental dietary supplementation of curcumin was accompanied by a decrease in the activation of apoptosis by cyclophosphamide, as well as a decrease in JNK activation. These results demonstrate that curcumin can inhibit chemotherapy-induced apoptosis by inhibiting ROS generation and blocking JNK function, effects which would be counterproductive for breast cancer patients undergoing chemotherapy [131]. 

Ramachandran, C. and You, W., Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin. Breast Cancer Res. Treat, 54 (3), 269-278,1999. 

Verma, S. R, Salamone, E., and Goldin, B., Curcumin and genistein, plant natural products, show synergestic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides, Biochem. Biophys. Res. Commun.( 991) 233(3), 692-696. 

When the surface of liposomes is functionalized with antibodies, the resulting immunoliposomes convey most of the encapsulated molecules to specific targeted cells, like cancer cells. The side effects of the anticancer drugs are thus reduced, and the action of the drug is potentialized. Recently, HER2-targeted immunoliposomes improved the bioavailability and selectivity of curcumin and res-veratrol, with a dramatic effect on the proliferation of human breast cancer cell lines. " ... 

Catania A, Barrajon-Cataldn E, Nicolosi S, Cicirata F, Micol V. Immunoliposome encapsulation increases cytotoxic activity and selectivity of curcumin and resveratrol against HER2 overexpressing human breast cancer cells. Breast Cancer Res Treat. 2013 141(l) 55-65. 

Sanoj et al. have investigated the in vitro anticancer potential of curcumin loaded onto biodegradable thermosensitive nanocarriers (Fig. 5) on oral cancer (KB), prostate cancer (PC3), and breast cancer (MCF-7) cell lines. They formulated... 

NCT01238198 Oral curcumin for radiation dermatitis in breast cancer patients... 

Bachmeier B, Nerlich AG, lancu CM, CUli M, Schleicher E, Vene R, Dell Eva R, Jochum M, Albini A, Pfeffer U (2007) The chtanopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice. Cell Physiol Biochem 19 137—152... 

Choudhuri, T., Pal, S., Agwarwal, M. L., Das, T., and Sa, G. 2002. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Letters, 512(1-3), 334-340. 

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