Stroke brain temperature

Minamisawa H., Mellergard P., Smith M. L., et al. (1990) Preservation of brain temperature during ischemia in rats. Stroke 21, 758-764. 

STUDIES ON BRAIN TEMPERATURE IN STROKE AND OTHER DISEASES... 

The body temperature limits for health in terms of internal or core temperature are fairly limited. The limits are basically related to the function of nervous tissue. Body temperatures around 28 °C or less can result in cardiac fibrillation and arrest. Temperatures of 43 °C and greater can result in heat stroke, brain damage, and death. Often, too high a temperature causes irreversible shape changes to the protein molecules of nervous tissue. That is, cooling overheated tissue to normal temperatures may not restore its original function. 

Heat stroke is the state in which heat stress induces a dangerously high core temperature that leads to tissue damage and particularly cerebral disturbance. The core temperature usually exceeds 40°C. The condition may follow heat exhaustion but the temperature rise may occur before salt or water depletion have had time to become manifest. Many organ systems may be affected by acute heat stroke including the brain, kidney, liver and muscles. Disturbance of the hypothalamic heat regulatory centre can lead to a loss of physiological responses to the... 

Ecstasy use is associated with physiological damage to a number of body systems. These include the heart, brain, liver, kidneys, and the body s ability to regulate temperature. Ecstasy increases heart rate and blood pressure, which is especially dangerous for someone with a known or unknown heart condition, but can also cause an irregular heartbeat in an ordinarily healthy person. An irregular heartbeat means the heart pumps less effectively therefore the blood flow to the brain and other organs is not adequate. This condition increases the risk for heart attack, stroke, and other types of heart failure. 

Elevated body temperature is one of the most toxic effects of ecstasy, and this risk is augmented by its use at dance parties and raves. The lack of air circulation in a crowded environment creates an elevated room temperature, which, together with increases in body temperature can cause brain toxicity similar to heat stroke. High body temperature can also lead to severe liver inflammation or damage, abnormal blood clotting, and death. 

Through its action on the dopamine and serotonin neurons in the brain, methamphetamine can cause paranoia, hallucinations, and severe mood disturbances. Methampethamine can also cause stroke through an increase in blood pressure, along with seizures. Other commonly seen side effects include irregular heart rate, damage to small blood vessels in the brain and eyes, and hyperthermia, which is an unregulated increase in the body s temperature. 

Meden P., Overgaard K., Pedersen H., and Boysen G. (1994) The influence of body temperature on infarct volume and thrombolytic therapy in a rat embolic stroke model. Brain Res. 647,131-138. 

It has been reported that increases in temperature may accentuate brain injury and worsen outcome following stroke and severe TBI (28-30). A recent study by Jiang etal. (31) looked at a number of factors that may play an important role in predicting outcome in 846 cases of severe TBI. In that study, the authors found that the outcomes were strongly... 

Individual susceptibility Individuals undergoing very stressful situations such as athletes/football players who practice in very hot temperatures, extensive workout for muscle building or people who fast to achieve weight loss are particularly susceptible. Ephedra puts an undue stress in these individuals by increasing the blood pressure and causing additional stress on the cardiovascular system, blood supply in the brain, which may result in heart attack or stroke. 

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