Brain developmental changes

Ramos, M., del Arco, A., Pardo, B. etal. Developmental changes in the Ca2+-regulated mitochondrial aspartate-glutamate carrier aralarl in brain and prominent expression in the spinal cord. Brain Res. Dev. Brain Res. 143 33-46, 2003. 

Malitschek, B., Riiegg, D., Heid, J., et al. (1998) Developmental changes in agonist affinity at GABAbR1 receptor variants in rat brain. Mol. Cell. Neurosci. 12,56-64. 

Tsukada (30) have examined developmental changes of the enzyme in chick brain and spinal cord. Enzymic activity appears at about the eighteenth day of incubation and increases rapidly until 3 days after hatching in the brain and between 18 and 21 days of incubation in the spinal cord. These are precisely the periods of active myelination in the brain and spinal cord of the chick, respectively. Similarly, brain tissue of the newborn rat is devoid of cyclic phosphate diesterase activity it appears at about 8 days after birth and increases dramatically between the tenth and thirty-fifth day of life (29). This coincides precisely with the development of myelin in this species. The diesterase is essentially absent in the brain of the jimpy mouse (31), a lethal mutant devoid of myelin in the central nervous system. It is also absent from the spinal cord of this mutant. The enzyme is about 50% deficient in brain tissue of the quaking mouse (29), a mutant with partial deficiency of myelin. There is no activity in nerve fibers and ganglia from a variety of invertebrates such as squid, octopus, crab, shrimp, and starfish. Nerve tissue in these organisms is nonmyelinated. All these observations point to an intimate association of the enzyme with myelin in vivo. 

Keep, R.F., et al. 1995. Developmental changes in blood-brain barrier potassium permeability in the rat Relation to brain growth. J Physiol 488 439. 

Villanueva, S. and Steward, 0. (2001) Protein synthesis at the synapse developmental changes, subcellular localization and regional distribution of polypeptides synthesized in isolated dendritic fragments. Brain Res. Mol. Brain Res. 91, 148-153. 

Kusuhara El, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SEi, Sugiyama Y, Kanai Y, Endou Ei. Molecular cloning and characterization of a new multispecific organic action transporter from rat brain. J Biol Chem 1999 274 13675-13680. Nakajima N, SekineT, Cha SEi,Tojo A, Eiosoyamada M, Kanai Y, Yan K, Awa S, Endou Ei. Developmental changes in multispecific organic anion transporter 1 expression in the rat kidney. Kidney Int 2000 57 1608-1616. 

Berthele A, Boxall SJ, Urban A, Anneser JMH, Zieglgansberger W, Urban L, Tdlle TR (1999) Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumber spinal cord. Dev Brain Res i 12 39-53. 

Takayama C, Nakagawa S, Watanabe M, Mishina M, Inoue Y (1996) Developmental changes in expression and distribution of the glutamate receptor channel 82 subunit according to the Purkinje cell maturation. Dev Brain Res 92 147-155. 

Paschen W, Schmitt J, Gissel C, Dux E (1997) Developmental changes of RNA editing of glutamate receptor subunits GluR5 and GluR6 in vivo versus in vitro. Dev Brain Res 98 271-280. 

Huttenlocher PR (1979) Synaptic density in human frontal cortex - developmental changes and effects of aging. Brain Res 163 195-205. 

Chugani DC, Muzik O, Behen ME, Rothermel RD, Lee J, Chugani HT (1999) Developmental changes in brain serotonin synthesis capacity in autistic and non-autistic children. Ann Neurol 45 287-295. 

Seto-Oshima A, Keino H, Kitajima S. Sano M, Mizutani A (1984) Developmental change of the immunoreac-tivity to anti-calmodulin antibody in the mouse brain. Acta Histochem. Cytochem., 17, 109-117. 

Hatanaka, H., Tsukui, H. and Nihonmatsu, 1. (1988) Developmental change in the nerve growth factor action from induction of choline acetyltransferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats. Dev. Brain Res. 39 85-95. 

Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain. / Cell Biol. 115 447 59. 

Stockli, K.A., Lillien, L.E., Naher-No6, M., Breitfeld, G., Hughes, R.A., Raff, M.C., Thoenen, H. and Sendtner, M. (1991) Regional distribution developmental changes and cellular localization of CNTF-mRNA and protein in the rat brain. 7. Cell Biol. 115 447 59. 

Ishikawa, R., Nishikori, K. and Furukawa, S. (1991a) Developmental changes in distribution of acidic fibroblast growth factor in rat brain evaluated by a sensitive two-site enzyme immunoassay. J. Neurochem. 56 836-841. 

Schmitt, J. et al.. Regional analysis of developmental changes in the extent of GluR6 mRNA editing in rat brain. Brain Res. Dev. Brain Res., 91, 153, 1996. 

K. Shiozaki, K. Koseki, K. Yamaguchi, M. Shiozaki, H. Narimatsu, and T. Miyagi, Developmental change of siaUdase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation, J. Biol. Chem., 284 (2009) 21157-21164. 

The stability of mature brain phosphatidate during ischemia appears to be a consequence of a developmental change and points to an interesting peculiarity in the membrane lipid metabolism of the newborn brain. Another feature of PA is that the incorporation of C-20 4 is slightly enhanced in homogenates of anoxic newborn brain while in most lipids the labeling is markedly diminished. Diacylglycerol shows a similar tendency, whereas in phosphatidyl inositol a more sharply reduced Incorporation has been observed. 

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