MRNA editing

Hyper-IgM syndrome can also arise if there is an intrinsic B cell defect that prevents B cells from switching to production of immunoglobulins other than IgM due to a mutation in the gene that codes for the mRNA-editing enzyme known as activation-induced cytidine deaminase (110). 

Phosphorylation by CaMKII (serine 1303) amino acids change due to mRNA edition... 

Changing Horses in Midstream Translational Frameshifting and mRNA Editing... 

Hodges, P. and Scott, J. (1992) Apolipoprotein B mRNA editing a new tier for the control of gene expression. Trends Biochem. Sci. 17, 77-81. 

Smith, H.C. and Sowden, M.P. (1996) Base modification mRNA editing through deamination - the good, the bad and the unregulated. Trends Genet. 12, 418 24. 

Regulation of Serotonin 2C Receptor PRE-mRNA Editing By Serotonin... 

Key Words Single-nucleotide polymorphisms mRNA editing alternative mRNA splicing posttranslational modifications 5HT2A, 5HT2C, and 5HT4 receptors. 

Genes can be altered posttranscriptionally by the processes of mRNA editing and alternative mRNA splicing. 

The functional significance of the various edited isoforms of the 5-HT2C receptor has been underscored by their differential abundances of expression in total brain and hypothalamic mRNA populations (293) and distinct functional properties. Moreover, the variant edited receptors exhibit differential abilities to bind various ligands, to mobilize intracellular Ca2+, and to stimulate hydrolysis of inositol phosphates (232,292,293). Bums and colleagues showed that mRNA editing of the 5-HT2C receptor leads to a 10- to 15-fold reduction in the efficacy of the interaction between receptors and their... 

Chan L, Chang HJ, Nakamuta M, et al. Apobec-l and apolipoprotein B mRNA editing. Biochim BiophysActa 1345 11-26,1997. 

The mRNA editing enz5one requires zinc (Xiong et ah, 1992 hmerarity elal, 1996). To compare some sizes, Apo B-48 (which is smaller than Apo B-100) is used to make chylomicrons (which are larger than VLDU). 

ApoB mRNA editing enzyme catalytic polypeptide 1... 

Since both hypermutation and switching are abohshed by AID deficiency, AID-directed mRNA editing could be required for these processes. Alternatively, AID-directed editing might occur while the immunoglobuhn transcripts are still attached to their genomic template. 

Yang, C.-C., Sklar, P., Axel, R. and Maniatis, A, 1997, Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing. Proceedings of The Natural Academy of Sciences. U.S.A. 94, 4354-4359. 

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