Bovine papilloma virus

Pavlakis, G.N. and Hamer, D.H. (1983). Regulation of metaUothionein-growth hormone hybrid gene in bovine papilloma virus. Proc. Natl. Acad. Sci. USA 80,397 401. 

AAPM = 2, 2 -azobis (2-amidino propane) dihydrochloride. BPV-4 = Bovine Papilloma Virus type 4. 

An extensive review of replication of plasmids derived from EBV and from bovine papilloma virus has recently been published (1) readers are referred to this review for a comparison of plasmid replication by these two viruses and for additional details of EBV plasmid replication. The present article will emphasize recent experiments that provide some insights into how the cis-and trans-acting components of the EBV replicon function. In addition, both published and potential applications of EBV-derived plasmid vectors will be discussed. 

Fig. 1. Survival curves of C127 cells transduced with a bovine papilloma virus alone (O) or bovine papillomavirus containing an hMT IIA gene construct ( ). Cells were treated for 72 h with the drugs and the number of cells determined by a colorimetric assay. (From Kelley et al. 1988, Overexpression of metallothionein confers resistance to anticancer drugs. Science 241 1813-1815)...

Lusky, M., Berg, L., Weiher, H., and Botchan, M., 1983, Bovine papilloma virus contains an activator of gene expression at the distal end of the early transcription unit. Mol. Cell. Biol. 3 1108-1122. 

Mammalian plasmid-based vectors, in addition to a prokaryotic replicon and a selection marker to permit DNA replication in E. coli, commonly have a eukaryotic replicon and a eukaryotic selection marker. The replicon usually comes from viruses such as Simian virus 40 (SV40), bovine papilloma virus (BPV) or Epstein Barr virus (EPV). The commonly used promoters are the SV40 early promoter (including its upstream enhancer... 

Baker, T. S., Newcomb, W. W., Olson, N. H., Cowsert, L. M., Olson, C., and Brown, J. G. (1991). Structures of bovine and human papilloma viruses Analysis by cryoelectron microscopy and three-dimensional image reconstruction. Cell 60, 1007-1015. 

Natural high-molecular weight sulphated or sulphonated PS, such as cellulose sulphate and dextran sulphate, may be useful non-toxic microbicidal compounds that are active against a variety of sexually-transmitted disease agents, including bovine papillomavirus type 1 and human papilloma virus type 11 and type 40 [111],... 

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