Bone tissue engineering strategy

Figure 6.1 An illustration of the typical process of bone tissue engineering strategy for the repair of cartilage defects.

Partridge, K. A., and Oreffo, R. O. C. (2004) Gene deliveiy in bone tissue engineering Progress and prospects using viral and nonviral strategies. Tissue Eng. 10, 295-307. 

Santos, M.I., Reis, R.L. Vascularization in bone tissue engineering physiology, current strategies, major hurdles and future challenges. Macromol. Biosci. 10, 12-27 (2010)... 

Porter JR, RuckhTT, Popat KC. (2009) Bone tissue engineering a review in bone biomimetics and drug delivery strategies. BiotechnoL Prog., 25 1539-1560. 

The efficacy of poly-3-hydroxybutyrate-co-3-valerate (PHBV) was evaluated by Cool et al. for bone tissue engineering. The in vitro osteogenic and inflammatory properties of PHBV were evaluated. The study revealed that the addition of nanosized reinforcing phase to PHBV improves osteogenic properties as well as reduces the proinflammatory response. This provides a new strategy for improving the suitability of PHBV-based materials for bone tissue regeneration. 

Janardhanan S, Wang MO, Fisher JP. Coculture strategies in bone tissue engineering the impact of culture conditions on pluripotent stem cell populations. Tissue Eng Part B Rev August 2012 18(4) 312-21. 

Shokrolahi, F., Mirzadeh, H., Yeganeh, H., Daliri, M., 2011. Fabrication of polyjurethane urea)-based scaffolds for bone tissue engineering by a combined strategy of using compression moulding and particulate leaching methods. Iranian Polymer Journal 20, 645-658. 

It has been reported that chitin-chitosan/nano Ti02-composite scaffolds has wide applications in tissue engineering field [85]. Current research has developed a novel immunoassay strategy based on combination of chitosan and a gold nanoparticle label [86] which explored the unanimous role of chitosan in biochemical research. Further bioinspired mineralization of chitosan-based nanocomplexes encouraged its role in bone tissue engineering applications [87]. Fabrication of chitosan/ZnO... 

The field of nanotechnology has a definite potential to significantly advance the field of bone tissue engineering (3). The current limitations in regenerative strategies include impaired cellular proliferation and differentiation, insufficient mechanical strength of scaffolds, and inadequate production of extrinsic factors necessary for efficient osteogenesis. 

Mistry, A. S., Mikas, A.G. Tissue Engineering Strategies for Bone Regeneration. Vol. 94, p.l... 

Mistry, A. S. and A. G. Mikos. 2005. Tissue engineering strategies for bone regeneration. Adv Biochem Eng Biotechnol 94 1-22. 

Similar to the ligament-to-bone interface, the tendon-to-bone interface (Figure 32.1) displays a zonal distribution of extracellular matrix components (Benjamin et al. 1986 Blevins et al. 1997). As such, while tendon-to-bone and ligament-to-bone insertions are physiologically and biochemically similar, the tissue engineering strategy applied is expected to differ as the two interfaces do vary in terms of... 

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