Bone stabilization

Alendronate (Fosamax) Anti-osteoporotic Bone stabilizer Tab 10.40 mg... 

Assistant Strengthen the bones, stabilize the Kidney-essence, expel wind, cold and dampness, stimulate and accelerate water metabolism and eliminate dampness, regulate the Qi... 

A number of reviews cover what has been achieved over the past 20 years in the field of soluble polymers as potential drug carriers.The polymers selected for preparing macromolecular prodrugs can be categorized according to (1) the chemical nature (vinylic or acrylic polymers, polysaccharides, poly(a-amino acids)) (2) the back bone stability (biodegradable polymers, stable polymers) (3) the origin (natural polymers, synthetic polymers) and (4) the... 

Histology In 54 patients who had fractures of the long bones stabilized with limited-contact dynamic compression plates made of titanium samples of the soft tissue layer covering the plate were recovered after 18 months [76 ]. The plates were covered by a connective tissue layer 2 mm thick on average. In patients with local pain there were significantly more round cells and macrophages, consistent with chronic granulomatous inflammation. 

Biological functions of Ca(Il) ion are numerous but maybe classified ia one of three categories the formation of soHd skeletal material such as bone, teeth, and shell the stabilizing of proteia conformational stmcture and the most varied, the abiUty of Ca(Il) to trigger certain physiological activities such as muscle contraction and the release of hormones (qv). 

One of the major drawbacks to many promising copolymers is their unsatisfactory electrochemical stability. Carbonyl groups which feature in many of the back-bone/chain linking groups are likely to cause stability concerns. Likewise, urethane, alcohol, and siloxane functions are sensitive to lithium metal. With this in mind, a recent trend has been to find synthetic routes to amorphous structures with... 

Taxanes (paclitaxel, docetaxel) are derivatives of yew tree bark (Taxus brevifolia). They stabilize microtubules in the polymerized state leading to nonfunctional microtubular bundles in the cell. Inhibition occurs during G2- and M-phases. Taxanes are also radiosensitizers. Unwanted effects include bone marrow suppression and cumulative neurotoxicity. 

There are approximately 200 other proteins present in bone, though most of them are present only in trace amounts (Delmas et al., 1984 Linde et al., 1980, as cited in van Klinken, 1991). The second most common bone protein, osteocalcin, comprises 1-2 weight % of total fresh bone. Osteocalcin bonds with both the bone mineral fraction and bone collagen, but it seems to be unstable in solutions. Due to its small molecular size and strong mineral stabilization, osteocalcin can survive up to 50.000 years (C.l. Smith et al., 2005), and it may offer an alternative to the use of collagen in paleoenvironmental stable isotope research. However, osteocalcin s role and importance in this field of study has yet to be defined (Collins et al., 2002). 

Selenium, which at present does not appear to be essential to man, apparently can be either beneficial or harmful to man, depending on very small differences in the concentrations. 13 Molybdenum can also be a boon or a detriment to health. It helps stabilize enamel and prevent caries in teeth, but also causes osteoporosis, a weakening of the bones.13... 

Emery, K. F., L. E. Wright, and H. Schwarcz (2000), Isotopic analysis of ancient deer bone Biotic stability in collapse period maya land use,. Archaeol. Sci. 27(6), 537-550. 

Docetaxel -semisynthetic taxane stabilizes tubulin polymers leading to death of mitotic cells -bone marrow suppression -nausea and vomiting -mucocutaneous effects (mucositis, stomatitis, diarrhea) -hypersensitivity reactions -fluid retention syndrome -fatigue -myalgias -alopecia (universal)... 

Exposed to 21.5 pg Pb/m3 air for one year Blood lead increased, but stabilized after 4 months lead levels remained elevated in bone, kidney, and liver after 6 months 13... 

Once osteopenia or osteoporosis develops, the objective is to stabilize or improve bone mass and strength and prevent fractures. 

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