Blurred vision ibuprofen

Ibuprcfen is thought to be better tolerated than aspirin and indomethacin and has been used in patients with a history of gastrointestinal intolerance to other NSAIDs. Nevertheless, 5-15% of patients experience GI side effects. Less frequent adverse effects include thrombocytopenia, rashes, headache, dizziness, blurred vision, and in a few cases toxic amblyopia, fluid retention, and edema. Patients who develop ocular disturbances should discontinue the use of ibuprofen. Ibuprofen can be used occasionally by pregnant women however, the concerns apply regarding third-trimester effects. Excretion into breast milk is thought to be minimal, so ibuprofen also can he used with caution by women who are breastfeeding. 

Adverse effects of naproxen is similar to that of ibuprofen. The most frequent adverse effects occuring are gastrointestinal disturbances. Peptric ulceration and gastro-intestinal bleeding have been reported, other side effects include headache, dizziness, nervousness, skin rash, pruritus, tinnitus, oedema, depression, drowsiness, insomnia, and blurred vision and other occular reactions. Hypersensitivity reactions, abnormalities of liver function tests, impairment of renal function including interstitial nephritis or the nephrotic-syndrome, agranulocytosis, and thrombocytopenia have occasionally been observed (5). 

An isolated report describes a man taking baclofen 20 mg three times a day, who developed baclofen toxicity (confusion, disorientation, bradycardia, blurred vision, hypotension and hypothermia) after taking 8 doses of ibuprofen 6(X) mg three times daily. It appeared that the toxicity was caused by ibuprofen-induced acute renal impairment leading to baclofen accumulation. Renal impairment is a relatively rare adverse effect of ibuprofen. The general importance of this interaction is likely to be very small. There appears to be no information about baclofen and other NSAIDs, and little reason for avoiding concurrent use. 

The treatment will have to be based on the adverse events. Physicians should discuss with their patients the potential adverse events associated with ibuprofen treatment. They should also advise patients to report to their physicians about signs and symptoms of chest pain, weakness, shortness of breath, slurred speech, gastrointestinal ulceration, bleeding, blurred vision or other eye symptoms, skin rash, weight gain, or edema. 

Blurred and diminished visions, scotomata, and changes in color vision have been reported with ibuprofen treatment. 

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