Bleeding effect

The polarity of the polyethers makes them incompatible with hydrocarbon-type plasticizers, which tend to bleed. Effective plasticizers are ethers such as di(butoxyethoxyethyl)formal [143-29-3] (Thiokors TP-90B), esters such as di(2-ethylhexyl) phthalate [117-81-7] dioctyl phthalate (DOP), polyesters such as Paraplex G50 (Rohm and Haas), and ether—esters such as di(butoxyethoxyethyl) adipate [114-17-3] (Thiokol s TP-95). The lower mol wt plasticizers, DOP, TP-90B, and TP-95 improve vulcanizate low temperature performance. The polymeric plasticizers maintain higher temperature and long-term aging properties. Epoxidized plasticizers should be avoided because they interfere with vulcanization. 

When fatty-acid or wax emulsion type damp-proofers are used in conjunction with lignosulfonate or hydroxycarboxylic-based admixtures, heavy air entrainment results with attendant strength reduction. Both these effects decrease waterproofing characteristics. At higher workabilities, ligno sulfonates counteract the reduced bleeding effect obtained with waxes and increase bleeding rates [83]. 

The coated ligand-exchange CSPs have been used with the mobile phases that did not cause bleeding effects. Otherwise, the CSP may lose its chiral ligand after a few runs [12]. It is very interesting to note that the values of separation factors were very high on the coated CSPs. The values of the separation factors for proline and valine amino acids were reported at 16.4 and 6.9, respectively... 

Standards and the recommended therapeutic dose. The antithrombotic potency and potential bleeding effects of one product cannot be extrapolated to another on the basis of weights in milligrams of anti-Xa or anti-IIa activities [34]. 

The addition of epinephrine, a vasoconstrictor, to an injectable anesthetic prolongs the duration of anesthesia and decreases the rate of systemic absorption, thereby decreasing the risk of systemic toxicity. The duration of some anesthetics, such as bupivacaine, a long-acting anesthetic, cannot be significantly extended by adding epinephrine. Epinephrine also decreases local bleeding. Effective vasoconstriction is obtained with a concentration of 1 to 100,000 or even 1 to 200,000. The usual... 

Since fector Xa has relatively slow activation kinetics, as opposed to thrombin, effecting its limction should result in easier management of the balance between the therapeutic and bleeding effects of a drag. From recent clinical trials thrombin inhibitors have shown to have a relatively narrow safety/efficacy margin which could lead to an overdose of the therapeutic dose with a resultant bleeding complication (57,58). Because of their different mechanism of action, factor Xa inhibitors are expected to ve a better efficacy/safety profile than thrombin inhibitors. 

In contrast to thrombin inhibitors, the fector Xa inhibitors are devoid of bleeding effects even at dosages much higher than supra-therapeutic levels, which in the case of heparin are responsible for bleeding. Thus, a dissociation between the bleeding and antithrombotic responses is clearly evident for both DX-9065a and pentasaccharide. 

Patients with accumulation of uremic toxins have increased sensitivity to certain drugs. There may be an enhanced response to CNS depressants (such as barbiturates and benzodiazepines), hemorrhagic effects from aspirin or warfarin, and other bleeding effects from antibiotics that inhibit platelet aggregation, such as carbenicillin, ticarcillin, and piperacillin. 

An example from the PR is the steroid ligand asoprisnil, which has been shown to produce antiuterotrophic effects with only minimal labor-inducing and breakthrough bleeding effects [76]. 

Stamenkovic, V. Grgur, B. N. Ross, P. N. Markovic, N. M. Oxygen reduction reaction on Pt and Pt-bimetallic electrodes covered by CO - Mechanism of the air bleed effect with reformate. J. Electrochem. Soc. 2005,152, A277-A282. 

Research to link chromatography directly to AMS continues at several institutions (Liberman et ah, 2007 Ognibene et ah, 2007 McIntyre et ah, 2009) and has great analytical appeal because chromatographic separations are continuous processes whose resolution is potentially diminished by collection of discrete time fractions. Better quantitative precision arises now from defined fractions whose isotope abundance is fixed by combustion and has no bleed effects from volumetric movement of fluids or gases. No baseline effects are seen for solid-sample AMS and the discrete fullerene samples do not cross contaminate. While direct LC connection is a goal, we show here that batch-produced chromatography samples from isolated fractions presents comparatively little loss in metabolite resolution. 

A feature related to viscosity is the resin bleed effect that has been observed with several die attach... 

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