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Bisulfite addition compound from

Aminoimidazo[l,2-a]pyrazine (456) has been prepared by the reaction of 2-aminopyrazine (455) with sodium cyanide and the bisulfite addition compound from formaldehyde (68TL3873). Another 3-aminoimidazo[l,2-a]pyrazine (458) was made by the reaction of the tetrahydropyrazine (457) with a-amino-a-cyanoacetamide (67MI41000, 67MIP41000). [Pg.643]

Miscellaneous Reactions. Sodium bisulfite adds to acetaldehyde to form a white crystalline addition compound, insoluble in ethyl alcohol and ether. This bisulfite addition compound is frequendy used to isolate and purify acetaldehyde, which may be regenerated with dilute acid. Hydrocyanic acid adds to acetaldehyde in the presence of an alkaU catalyst to form cyanohydrin the cyanohydrin may also be prepared from sodium cyanide and the bisulfite addition compound. Acrylonittile [107-13-1] (qv) can be made from acetaldehyde and hydrocyanic acid by heating the cyanohydrin that is formed to 600—700°C (77). Alanine [302-72-7] can be prepared by the reaction of an ammonium salt and an alkaU metal cyanide with acetaldehyde this is a general method for the preparation of a-amino acids called the Strecker amino acids synthesis. Grignard reagents add readily to acetaldehyde, the final product being a secondary alcohol. Thioacetaldehyde [2765-04-0] is formed by reaction of acetaldehyde with hydrogen sulfide thioacetaldehyde polymerizes readily to the trimer. [Pg.51]

Nature Identical Flavor Matenal A flavor ingredient obtained by synthesis, or isolated from natural products through chemical processes, chemically identical to the substance present in a natural product and intended for human consumption either processed or not eg, citral obtained by chemical synthesis or from oil of lemongrass through a bisulfite addition compound. [Pg.19]

Ketones are more stable to oxidation than aldehydes and can be purified from oxidisable impurities by refluxing with potassium permanganate until the colour persists, followed by shaking with sodium carbonate (to remove acidic impurities) and distilling. Traces of water can be removed with type 4A Linde molecular sieves. Ketones which are solids can be purified by crystallisation from alcohol, toluene, or petroleum ether, and are usually sufficiently volatile for sublimation in vacuum. Ketones can be further purified via their bisulfite, semicarbazone or oxime derivatives (vide supra). The bisulfite addition compounds are formed only by aldehydes and methyl ketones but they are readily hydrolysed in dilute acid or alkali. [Pg.67]

Impurities resulting from storage can be removed by passage through chromatographic grade alumina. Furfural can be separated from impurities other than carbonyl compounds by the bisulfite addition compound. The aldehyde is steam volatile. [Pg.249]

The sodium bisulfite addition compounds must have a free (or potentially free) ketone-type carbonyl group, since they readily form derivatives with typical ketone reagents such as semicarbazide and 2,4-dinitrophenylhydrazine.174 Decomposition of these derivatives with alkali gives the corresponding adrenochrome derivatives e.g., adrenochrome monosemicarbazone would be obtained from the semicarbazone of the adrenochrome-sodium bisulfite complex.174 If one accepts Tse and Oesterling s formulation of the adrenochrome-sodium bisulfite complex, the semicarbazone would probably have a basically similar structure (i.e. 82). This type of structure is more... [Pg.267]

The sodium bisulfite purification step may be omitted, and the alkylidene ester purified directly by distillation. Care must be taken to separate the product from ethyl cyanoacetate by fractionation through a moderately efficient column. Purification through the bisulfite addition compound is recommended for alkylidene cyanoacetic esters derived from ketones containing four and five carbon atoms, but not for the higher homologs. [Pg.48]

Seventeen grams of acetaldehyde are dissolved in 20ml of water and added dropwise to a suspension of 40g of sodium bisulfite in 30ml of water. The reaction mixture is kept cold in an ice bath to prevent loss of the aldehyde by volatilization much heat Is liberated by the formation of the bisulfite addition compound. The temperature of the solution is adjusted to 50°C and 17ml of 20% aqueous ammonia are added. The latter is prepared from 13ml of the... [Pg.137]

The yields of nitro alcohols from simple nitroparaffins and aliphatic aldehydes or benzaldehyde are usually above 60%. The condensations are generally carried out with aqueous ethanolic sodium hydroxide, although weaker bases are sometimes desirable to prevent polymerization of the aldehyde. Sodium bisulfite addition compounds of the aldehydes are sometimes used. Better results are obtained with sodium methoxide than with alkali hydroxides in the condensation of nitroethane with formaldehyde. Sodium alkoxides are also used to effect the condensation of nitroethane with acetone and cyclohexanone. Condensation proceeds to the nitroalkanediol stage in certain cases with both nitromethane and with formaldehyde. ... [Pg.93]

Since these bisulfite addition compounds are ionic water-soluble compounds and can be formed in up to 90% yield, they serve as a useful means of separating aldehydes and methyl ketones from mixtures of organic compounds. At high sodium bisulfite concentrations these adducts crystallize and can be isolated by filtration. The aldehyde or ketone can be regenerated by adding either a strong acid or base ... [Pg.303]

Hinsberg oxindolc synthesis. Formation of oxindoles from secondary aryl amines and sodium bisulfite addition compound of glyoxal primary aryl amines give glycine or glycinamide derivatives. [Pg.652]

The best derivative from which an aldehyde can be recovered readily is its bisulfite addition compound, the main disadvantage being the lack of a sharp melting point. The aldehyde (sometimes in ethanol) is shaken with a cold saturated solution of sodium bisulfite until no more solid adduct separates. The adduct is filtered off, washed with a little water, followed by alcohol. A better reagent to use is a freshly prepared saturated aqueous sodium bisulfite solution to which 75% ethanol is added to near-saturation. (Water may have to be added dropwise to render this solution clear.) With this reagent the aldehyde need not be dissolved separately in alcohol and the adduct is finally washed with alcohol. The aldehyde is recovered by dissolving the adduct in the least volume of water and adding an equivalent quantity of sodium carbonate (not sodium hydroxide) or concentrated hydrochloric acid to react with the bisulfite, followed by steam distillation or solvent extraction. [Pg.65]

Ingles heated a solution of n-glucose, sodium sulfite, and bisulfite, removed the cations, and steam-distilled the residue. The product, free of carbonyl-bisulfite addition compounds, was chromatographed on an ion-exchange resin, giving a sulfonic acid. This acid yields a crystalline brucine salt and phenyl- and (2,4-dinitrophenyl)-osazones. The osazones consume 1 mole of periodate per mole, liberating 1 mole of formaldehyde but no formic acid. The (2,4-dinitrophenyl)osazone also forms a diacetate. The acid is oxidized by sodium hypoiodite, taking up 1 mole of oxidant per mole. From these reactions and the possible reaction mechanisms for its formation, structure (41), a 3,4-dideoxy-4-sulfo-n-hexosulose, was proposed for the sulfonic acid. ... [Pg.197]


See other pages where Bisulfite addition compound from is mentioned: [Pg.22]    [Pg.57]    [Pg.179]    [Pg.299]    [Pg.83]    [Pg.264]    [Pg.21]    [Pg.57]    [Pg.179]    [Pg.299]    [Pg.350]    [Pg.806]    [Pg.1336]    [Pg.23]    [Pg.167]    [Pg.205]    [Pg.336]    [Pg.25]    [Pg.75]    [Pg.188]    [Pg.232]    [Pg.379]    [Pg.25]    [Pg.75]    [Pg.188]   
See also in sourсe #XX -- [ Pg.149 ]

See also in sourсe #XX -- [ Pg.149 ]




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