Biotransformations in the Preparation of Compounds Labeled with Carbon and Hydrogen Isotopes

Biotransformations in the Preparation of Compounds Labeled with Carbon and Hydrogen Isotopes 

Biotransfonnations are selective chemical modifications of molecules by biological entities ranging from isolated enzymes (ceU-free systems) to intact organisms. In particular cases they are exploited by the chemical and pharmaceutical industries for production of chemicals this approach can be especially advantageous for structurally complex compounds. Preparative biotransformations have been used on a laboratory scale by radiochemists to prepare isotopically labeled compounds necessary for drug development and other applications in the life sciences. Their synthetic use for isotope labeling includes  

As the complexity of the biological system varies from highly purified enzymes to whole cell-containing systems, so do some of the practical dimensions of the experiments vary. Therefore this chapter is organized accordingly. 

Preparation of Compoimds Labeled with Tritium and Carbon-14 Rolf Voges, J. Richard Keys and Thomas Moemus 2009 John Wiley Sons, Ltd. ISBN 978-0-470-51607-2 

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