Biosensors Using Lasers

Biosensors Using Lasers, Fig. 1 The biosensor comprises a biorecognition molecular layer immobilized on the interface of a signal transducer. Biological change on this interface is converted into a detectable signal and... 

Biosensors Using Lasers, Fig. 3 (a), SPR curve of a detection method based on incident angle scan. SPR angle shifts with the change in refractive index, (b), monitoring the shift of SPR angle in real time... 

Biosensors Using Lasers, Fig. 4 Fiber-optic biosensors based on (a) absorbance and (b) fluorescence detection... 

Biosensors Using Lasers, Fig. 6 Schematic of a laser-based biosensor using the resonant Bragg reflector principle. A receptor molecular layer covers the surface of some corrugation that is used as sensing materials. After some... 

Biosensors Using Lasers, Fig. 7 Scheme of the optical readout method for a microcantilever bending evaluation. The displacement of the free end of the cantilever is measured by monitoring the optical deflection of an incident laser beam on a position-sensitive detector... 

Biosensors Using Lasers, Fig. 8 Working principle of the microcantilever atomic force biosensor... 

In recent years, laser-based biosensors have become important tools in many fields such as analytical biochemistry, pharmaceutical research and development, and food/environ-mental monitoring. However, the volumes of the optic components in these biosensors limit their application in portable microdevices. In order to obtain more powerful, miniaturized, and cheaper biosensors using lasers, novel biological sensing principles, detection means, and fabrication methods need to be sought. The integration of biosensors and microfluidic chips will be an important direction for developments in laser-based biosensors. Biosensors can be used as microscale detection tools in lab-on-a-chip for the research and development of miniaturized detection devices, i.e., micro-total analysis systems. 

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