BIOMOLECULAR RESEARCH

The overall scope of this book is the implementation and application of available theoretical and computational methods toward understanding the structure, dynamics, and function of biological molecules, namely proteins, nucleic acids, carbohydrates, and membranes. The large number of computational tools already available in computational chemistry preclude covering all topics, as Schleyer et al. are doing in The Encyclopedia of Computational Chemistry [23]. Instead, we have attempted to create a book that covers currently available theoretical methods applicable to biomolecular research along with the appropriate computational applications. We have designed it to focus on the area of biomolecular computations with emphasis on the special requirements associated with the treatment of macromolecules. 

BioMolecular research tools—A collection of WWW links to information and services useful to molecular biologists http //www.public.iastate.edu/ pedro/research tools.html... 

The World Wide Web has transformed the way in which we obtain and analyze published information on proteins. What only a few years ago would take days or weeks and require the use of expensive computer workstations can now be achieved in a few minutes or hours using personal computers, both PCs and Macintosh, connected to the internet. The Web contains hundreds of sites of Interest to molecular biologists, many of which are listed in Pedro s BioMolecular Research Tools (http // www.fmi.ch/biology/research tools.html). Many sites provide free access to databases that make it very easy to obtain information on structurally related proteins, the amino acid sequences of homologous proteins, relevant literature references, medical information and metabolic pathways. This development has opened up new opportunities for even non-specialists to view and manipulate a structure of interest or to carry out amino-acid sequence comparisons, and one can now rapidly obtain an overview of a particular area of molecular biology. We shall here describe some Web sites that are of interest from a structural point of view. Updated links to these sites can be found in the Introduction to Protein Structure Web site (http // WWW.ProteinStructure.com/). 

Corresponding author Krebs Institute for Biomolecular Research and Department of Information Studies, University of Sheffield, Western Bank, Sheffield SIO 2TN, UK. 

Biomolecular Research Institute, Parkville, Victoria, Australia... 

Pedro s Biomolecular Research Tools http //zvww.fmi.ch/biology/research tools.html... 

Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom... 

Dq>artinent of Microbiology and Biomolecular Research Facility, University of Virginia Medical School, Charlottesville, VA... 

The current 4 epoch of liver research may later be known as biomolecular hepatology . Not only examination techniques based on biochemistry, histology and imaging, but also the therapy of liver disease will increasingly be determined by biomolecular research. 

Biological mass spec/ U. Washington Pedro s Biomolecular Research Tools... 

National Cen ter for Biomolecular Research, Faculty of Science. Masaryk University, Kotldfskd 2, CZ-61137 Bmo. Czech Republic... 

The use of the facilities of the Institut fur Makromolekulare Chemie, Freiburg, West Germany, for the polymer fractionations is also gratefully acknowledged. The high field NMR experiments were performed at the NMR Facility for Biomolecular Research located at the F. Bitter National Magnet Laboratory, M.I.T. 

Patent Number WO 9534595 A1 19951221 ANTIVIRAL DENDRIMERS Matthews B R Holan G Biomolecular Research Institute Ltd. 

Microarray is a rapidly developing field, with the capacity to revolutionize many fields of biomolecular research. This technology promises to deliver an explosion of information on the genetic basis of normal physiological processes and disease states by providing the opportunity to simultaneously compare the relative amounts of thousands of individual sequences from complex mixtures of nucleic acids. Based on traditional nucleic acid hybridization chemistry, it offers flexibility in choice of target/probe combinations and provides quantifiable data on relative expression levels. 

Bijvoet Center for Biomolecular Research, Department of Bio-organic Chemistry, RO. Box 80.075, 3508 TB Utrecht, The Netherlands... 

Center for Biostructural and Biomolecular Research, University of Western Sydney, Hawkesbuiy, Richmond,... 

Pierre C. Havugimana, Banting and Best Department of Medical Research, Department of Medical Genetics and Microbiology, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Enhanced Proteomic Analysis by HPLC Prefractionation... 

The increasingly stringent environmental requirements demand new catalytic synthetic processes as does the necessity to produce the novel types of organic compounds generated in biomolecular research as active molecules or targets. Enzyme-catalyzed chemical trans-... 

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