Biomaterials graft copolymerization

It is inferred that carboxyl ligands are important in the binding of metal ions. Thus, increasing the nmnber of such groups should increase the biomaterial-binding ability. This is achieved through succination, acetylation, and graft copolymerization of the biomaterial. 

The conversion of the amino group into amide (3289.77-3365.14 cm ) confirmed the acetylation process. The appearance of a characteristic peak at 1725.2 cm (C = 0) in the IR spectra of the graft copolymerized biomaterial compared with its unmodified biomaterial, and this confirmed the formation of the grafted biomaterial (Figure 3.7). 

The increased stability of the graft copolymerized biomaterial has been monitored on the basis of an increase in the number of regeneration cycles. Structurally modified biomaterial (polymerized) could be used up to six times as compared to only four times of unmodified biomaterial, thereby exhibiting the increased environmental stability of the polymerized biosorbent (Table 3.3). 

Sorption of Cationic Metal Ion on Regenerated Modified (Graft Copolymerized) Biomaterial... 

Hsuie, G.H. Lee, S.D. Chang, P.C. Kao, C.Y. Surface characterization and biological properties study of silicone rubber material grafted with phospholipid as biomaterial via plasma induced graft copolymerization. J. Biomed. Mater. Res. 1998, 42, 134-147. 

Biomaterials must be free from elutable impurities, such as additives and residual substances. Additives include stabilizers, antioxidants, plasticizers, and fillers which are added to commercial polymers to impart specific physical or mechanical properties. Since long- and short-term migration of these components to the adjacent tissues and biological fluids is highly undesirable, additives must be eliminated before use. In addition, favorable polymer properties can be achieved without using additives via block or random copolymerization of the candidate homopolymer with other monomers. Graft copolymerization is also used to obtain polymer surfaces with... 

There are three basic processes which are utilized for preparing new or modilled polymeric biomaterials. They are (1) surface modification via radiation graft copolymerization or plasma gas discharge (2) radiation polymerization of pure monomeifs) in solution, or an emulsion, or in the solid state (e.g., below Tq) and (3) radiation crosslinking, in a solution or swollen state, or in the solid state. 

Lora S, Carenza M, Palma G, Caliceti P, Battaglia P and Lora A, Biocompatible polyphosphazene by radiation-induced graft copolymerization and heparinization , Biomaterials, 1991, 12, 275-80. 

Morikawa, N., Matsuda, T. (2002). Thermoresponsive artificial extracellular matrix A-isopropylacrylamide-graft-copolymerized gelatin. Joumai of Biomaterial Science Polymer Edition, 13, 167-183. 

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