Biomarkers gastric cancer

H, YU s z and kurtz r c (2000) GSTTl and GSTMl null genotypes and the risk of gastric cancer a case-control study in a Chinese population . Cancer Epidemiol Biomarkers Prev, 9 73-80. 

Larsson SC, Bergkvist L and Wolk A. 2006. Fruit and vegetable consumption and incidence of gastric cancer a prospective study. Cancer Epidimiol Biomarkers Prev 15(10) 1998—2001. 

Molecular risk biomarkers could detect systemic or local changes indicating that the carrier of this specific biomarker is at higher risk for disease development in the future. Examples include the presence of human papillomavirus in the cervix, which is associated with a higher risk for the development of cervical cancer, the association between Hdicohacterpylori and gastric cancer as well as EBV and nasopharyngeal carcinoma. The drawback of these markers is that they are not helpful for the detection of early disease. 

LOX has been found to be an important marker for cancer progression within the melanoma system, and therefore could be a useful biomarker and therapeutic target for melanoma chemoprevention (Winer et al., 2002). It also has been found that 12(S)-HETE is involved in the proliferation of pancreatic carcinoma cells (Ding et al., 2001) and inhibition of the 12-LOX has been shown to cause apoptosis of these cells (Tong et ah, 2002). 12-LOX and 12(S)-HETE were also found to enhance proliferation and survival of gastric cancer cell lines (Wong et al., 2001). 

Bosetti C, Callus S, Talamini R, Montella M, Franceschi S, Negri E, La Vecchia C. Artificial sweeteners and the risk of gastric, pancreatic, and endometrial cancers in Italy. Cancer Epidemiol Biomarkers Prev 2009 18(8) 2235-8. 

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