Melanoma chemoprevention

LOX has been found to be an important marker for cancer progression within the melanoma system, and therefore could be a useful biomarker and therapeutic target for melanoma chemoprevention (Winer et al., 2002). It also has been found that 12(S)-HETE is involved in the proliferation of pancreatic carcinoma cells (Ding et al., 2001) and inhibition of the 12-LOX has been shown to cause apoptosis of these cells (Tong et ah, 2002). 12-LOX and 12(S)-HETE were also found to enhance proliferation and survival of gastric cancer cell lines (Wong et al., 2001). 

Halpem, A. G., Retinoids and the chemoprevention of melanoma, in Advances in the Biology and Treatment cf Cutaneous Melanoma, Meeting Abstracts, Boston, MA, November 6 and 7,1998. 

Finally, chemoprevention with systemic retinoids has demonstrated promise in decreasing the incidence of new primary non-melanoma skin cancers (NMSCs) in immxmocompromised post-transplantation recipients. However, there is limited evidence for the use of systemic retinoids in the non-transplantation patients at high risk for NMSC. This study was designed as prospective, randomised, double-blind, placebo-controlled clinical trial [3. ... 

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