Biological correlations

P.N. Craig, Comparison of the Hansch and Free-Wilson approaches to structure-activity correlation, In Biological Correlations — The Hansch Approach (R.F. Gould, Ed.). Advances in Chemistry Series, No. 114. American Chemical Society, Washington DC, 1972, pp. 115-129. P.N. Craig, Interdependence between physical parameters and selection of substituent groups for correlation studies. J. Med. Chem., 14 (1971) 680-684. 

The pathological response rate of chemo-RT compares favorably with that of any reported contemporary chemotherapy neo-adjuvant trial in this patient population (15-20). In addition, this study proved the feasibility of using biological correlates from pretreatment tumor biopsies to explore associations with pathological response. In fact, 11/21 patients (52%) with no evidence ofp53 overexpression at immunohistochemistry achieved a pathological response to the regimen, compared to 1/14 patients (7%) with overexpressed p53 (p = 0.010, Fisher exact text). 

FormentiSC, Uziely B, DunningtonG, etal. Continuous infusion (ci) 5-fluorouracil (FU) with radiation in locally advanced breast cancer clinicopathological and biological correlates (Meeting abstract). 

Ad.TNF gene therapy is presently in clinical trials in patients receiving radiotherapy. An open-label, phase I, dose-escalation study of tumor necrosis factor-alpha (TNFerade) gene transfer with radiation therapy for locally advanced, recurrent, or metastatic solid tumors is currently accruing patients and has several endpoints (82), including toxicity and tolerable dose. Pharmacokinetics will be evaluated and biological correlates will determine the histologic response to therapy. 

Hornig-Rohan M, Amsterdam JD Clinical and biological correlates of treatment-resistant depression an overview. J Clin Psychiatry 24 220-227, 1994 Horowski R, Wachtel L, Turski L, et al Glutamate excitotoxicity as a possible pathogenetic mechanism in chronic neurodegeneration, in Neurodegenerative Diseases. Edited by Caine DB. Philadelphia, PA, WB Saunders, 1994, pp 163-174... 

Sakkas PN, Soldatos CR, Bergiannaki JD, et al In search of the adaptation effect sleep patterns of normal individuals and depressed patients, in Psychiatry A World Perspective, Vol 2 Neuroscience in Psychiatry Biological Correlates of Mental Disorders. Edited by Stefanis CN, Soldatos CR, Rabavilas AD. New York, Excerpta Medica, 1990, pp 380-385... 

M. S. Keshavan, J. W. Pettegrew, C. F. Reynolds, III, K. S. Panchalingam, D. Montrose, J. Miewald and D. J. Kupfer, Biological correlates of slow wave sleep deficits in functional psychoses P-magnetic resonance spectroscopy. Psychiatry Res., 1995, 57, 91-100. 

Lieberman JA, Saltz BL, Johns CA, et al The effects of clozapine on tardive dyskinesia. Br J Psychiatry 158 503-510, 1991 Lieberman J, Jody D, Geisler S, et al Time course and biologic correlates of treatment response in first-episode schizophrenia. Arch Gen Psychiatry 50 369-376, 1993... 

S. C. Basak, D. K. Harris, V. R. Magnuson (1984). Comparative study of hpophilicity versus topological molecular descriptors in biological correlations. J. Pharm. Sci. 73 429-437. 

Post RM, Rubinow DR, Uhde TW, et al. Dysphoric mania clinical and biological correlates. Arch Gen Psychiatry 1989 46 353-358. 

Kupfer DJ, Frank E, Me Eachran AB, Grochocinski VJ (1990) Delta sleep ratio a biological correlate of early recurrence in unipolar affective disorder. Arch Gen Psychiatry 47 1100-1105... 

Gould, R.G.E. Biological Correlations - The Hansch Approach. Advances in Chemistry, 1972,114, The American Chemical Society. 

In Biological Correlations—The Hansch Approach Van Valkenburg, W. Advances in Chemistry American Chemical Society Washington, DC, 1974. 

Similar substituent effects are observed for the anti-MAO activity of / -carbolines and pargyline derivatives (47). In Equation 25, E 6 8 is the sum of values of the 6 and 8 substituents, and o-4b is the o- value of substituents to the 4b position. In Equation 26, E84 corresponds to the para substituent and o-2 to the ortho position of the side chain. The coincidence in the stereoelectronic effects of substituents on the MAO inhibition is surprisingly good for these three classes of inhibitors. On the structural formulas shown above, the arrows indicate positions where the a values are directed, and the shaded circles show sterically limited positions. Thus, the individual correlations are substantiated, and physicochemical significance is proved by similar biological correlations. 

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