Biological cytotoxic activity

There has been considerable interest in pyridoacridines and related compounds owing to their biological activity (cytotoxicity, mutagenicity, or antibacterial activity). Wawer and coworkers [127] reported the study of a pair of quinoacridinium salts from this... 

Keywords antibacterial, biological activity, cytotoxic, marine brominated alkaloids, marine natural products, nematocidal, organohalogens, pharmaceuticals, tyrosine derived alkaloids... 

BIOLOGICAL ACTIVITY Cytotoxicity [1752] KB, human oral epidermoid carcinoma [1752]. 

Since the pioneer work by Merigan in 1967 [1], many kinds of synthetic or natural polyanionic polymers have been examined for their biological activities [2-8], such as cytotoxicity, antiviral activity, antitumor activity, and immunomodulating activity. Although the biological results were interesting, the extent of activity for clinical application was still low. 

There are numerous examples of intramolecular Heck reactions,151 such as in Entries 10 to 14. Entry 11 is part of a synthesis of the antitumor agent camptothecin. The Heck reaction gives an 11 1 endocyclic-exocyclic mixture. Entries 12-14 are also steps in syntheses of biologically active substances. Entry 12 is part of a synthesis of maritidine, an alkaloid with cytotoxic properties the reaction in Entry 13 is on a route to galanthamine, a potential candidate for treatment of Alzheimer s disease and Entry 14 is a key step in the synthesis of a potent antitumor agent isolated from a marine organism. 

Composites -have been reported (8) to contain a wide variety of sesquiterpene lactones and lactones of this type have been previously found in both Russian knapweed and yellow starthistle (9,10,11,12). The wide range of biological activity associated with sesquiterpene lactones, e.g., cytotoxicity, phytotoxicity, antineoplasticity, etc. (8) suggested the possibility that these compounds may play a role in the allelopathy of both Russian knapweed and yellow starthistle. 

Effects of Sesquiterpene Lactones on Seed Germination. Sesquiterpene lactones are common constituents of the Asteraceae but are also found in other angiosperm families and in certain liverworts (31,32). These highly bitter substances exhibit a wide spectrum of biological activities (J 3) which include cytotoxicity, anti-tumor, anti-microbial, insecticidal (34) and molluscicidal (35) properties. Furthermore, they are known causes for livestock poisoning and contact dermatitis in humans (33). Structure-activity relationship studies on sesquiterpene lactones have demonstrated that biological activity frequently depend on the presence of the cr... 

Thiosemicarbazone (RNH-CS-NH-N=CR/R//, tsc) complexes of cobalt(III) have been extensively studied since the early 1980s and continue to attract attention, gaining particularly from an interest in their biological activity and potential cytotoxicity. A truly extensive range of tsc compounds has now been reported, although structural definition of their complexes widely relied on basic analytical and spectroscopic techniques up to the late 1980s, when X-ray crystal structural studies of tsc compounds became more common. A review of thiosemicarbazone and S-alkyldithiocarbazate complexes has appeared.1053... 

A variety of substituted dibenzo-fused derivatives 126 have been prepared for evaluation of their biological activities. The synthesis of these compounds involves the reaction of o-acylanilines with pyrroloindolones 125, in boiling butan-l-ol with pyridinium />-toluenesulfonate as catalyst (Equation 8). Compounds such as 126 which contain the benzo[5,6]pyrrolizino[l,2-A]quinoline skeleton exhibit cytotoxicity against several cancer cell lines <2004BML2363>. 

Pyridazines continued to play a central role in the construction of new biologically active compounds. 2,7-Dihydro-3//-pyridazino 5,4,3-17 acridin-3-ones were synthesized as cytotoxic agents <05BMC1969> and 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2//-... 

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