Bioinformatics information technology

The current situation in bioinformatics is characterized by an avalanche of DNA sequences from the human genome project and similar programs and, consequently, an exponential increase in DNA sequences but only a linear increase in protein 3D structures. While multitudes of putative genes have been annotated, up to 90% of all known DNA sequences have no assigned, i.e., experimentally proven, function. From this situation arise the need for interpretation of DNA sequences by information technology, and moreover, analysis of functional genomics and proteomics (see Chapter 15). 

Since the arrival of information technology, biochemistry has evolved from an interdisciplinary role to becoming a core program for a new generation of interdisciplinary courses such as bioinformatics and computational biochemistry. A demand exists for an introductory text presenting a unified approach for the combined subjects that meets the need of undergraduate science and biomedical students. 

Bioinformatics The use of information technology to analyze data obtained from proteomic analysis. An example is the use of databases such as SWISSPROT to identify proteins from sequence information determined by the mass spec-trometric analysis of peptides. See Wang, J.T.L., Data Mining in Bioinformatics, Springer, London, 2005 Lesk, A.M., Introduction to Bioinformatics, Oxford University Press, New York, 2005 Englbrecht, C.C. and Facius, A., Bioinformatics challenges in proteomics. Comb. Chem. High... 

It is perhaps not necessary to emphasize that bioinformatics in its widest acceptation i.e. algorithms and information technology (graphics visualization, relational database), given the combinatorial aspect of the PPI has been utilized intensively as a companion to the many different PPI discovery methods. We will give some examples and flavour of the different use of bioinformatics tools to predict, analyse and/or validate PPI. 

Bioinformatics can be broadly described as the application of information technology to the field of molecular biology. It aims to solve practical problems arising from the management and analysis of biological data, such as natural products with pharmacological or biological activities. 

Profile A bioinformatics company, Pangea applies information technology to biological research. Software applications integrate data with analysis and visualization tools for biological and chemical information. Incorporated in 1993, it is a privately held company. 

EMBS Publications include EMB Magazine, and a number of IEEE Transactions Biomedical Engineering, Information Technology in Biomedicine, Neural Systems and Rehabilitation Engineering, Medical Imaging, Nanobioscience, Computational Biology and Bioinformatics, and Biomedical Circuits and Systems. 

Vassiliev PM (2009) Information technology for prediction of pharmacological activity of chemical compounds. Dissertation, Volgograd State Medical University Vassiliev PM (2012) IT Microcosm for property prediction of organic compounds. In Proceedings of the 2nd French-Russian workshop in chemoinformatics and bioinformatics, KFU, Kazan, 17 Sept 2012, pp 8-9... 

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