Discovery methods

Kitchen DB, Decornez H, Furr JR, Bajorath J. Docking and scoring in virtual screening for drug discovery methods and applications. Nat Rev Drug Discov 2004 3(ll) 935-49. 

Mannhold R, Berellini G, Carosati E, Benedetti P (2005) In Craciani G (ed) Molecular interaction fields in drag discovery (Methods and Principles in Medicinal Chemistry), vol 27. Wiley, Weinheim, Germany, p 173... 

Yan Q (2008) The integration of personalized and systems medicine bioinformatics support for pharmacogenomics and drug discovery. Methods Mol Biol 448 1-19... 

Researchers at Sunesis pharmaceuticals have developed a fragment-based drug discovery method termed tethering [25]. The approach, which is illustrated in Scheme 2.6, shares a number of features with DCC. Whereas protein-directed DCLs equilibrate small molecules via disulfide formation, say, in the presence of a protein that acts as a thermodynamic trap, tethering uses a cysteine residue on the protein surface to reversibly capture small-molecule thiol fragments from solution. Tethering is designed... 

Babine, R. E. and Abdel-Meguid, S. S., eds. (2004). Protein crystallography in drug discovery. Methods and Principles in Medicinal Chemistry, Vol. 20. Wiley-VCH. 

Waugh, S. M. and Fletterick, R. J. (2004). Crystalhzation and analysis of serine proteases with ecotin. In Protein Crystallography in Drug Discovery. Methods and Principles... 

Jurgen Moll and Riccardo Colombo (eds.), Target Identification and Validation in Drug Discovery Methods and Protocols, Methods in Molecular Biology, vol. 986, DO110.1007/978-1 -62703-311 -4 1, Springer Science+Business Media New York 2013... 

Ekins, S., Mestres, J., Testa, B. In silico pharmacology for drug discovery methods for virtual ligand screening and profiling. Br. J. Pharmacol. 2007, 152, 9-20. 

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