Biohybrid system

The study of the self-assembly behavior of amphiphilic molecules, macromolecules and biohybrid systems, has led to the discovery of numerous spectacular and stunning nanometer and micrometer sized architectures. Only when the basic rules relating the resultant... 

This paper reports on the development of membrane systems to be used for cell culture (e.g., hepatocytes, lymphocytes, neuronal cells) in biohybrid systems such as a therapeutic device or as in-vitro model systems for studying the effects of various drugs and chemicals on cell metabolism. 

In the last few years the use of membrane biohybrid systems has contributed to giving important information about the effect of various drugs, such as diclofenac, rofecoxib, paracetamol the effects of which on the specific functions of human hepatocyte are not completely known [17-21],... 

A protocol of isolation and culture of hippocampal neurons has been optimized by using a hibernating rodent, the hamster Mesocricetus auratus as our animal model [57]. Preliminary results demonstrated the feasibility of culturing hippocampal neurons in a membrane biohybrid system. The substrate is of great importance for the survival and differentiation of neuronal cultures. As substrate we used a gas-permeable (C02, 02, and H20 vapor) fluorocarbon foil membrane (FC), modified with a coating of poly-L-lysine in order to improve the interactions with cells. 

This study reports on the potentiality of applying a membrane biohybrid system in the field of tissue engineering and regenerative medicine evidencing the crucial points in the in-vitro reconstruction of the physiological tissue model. A number of issues need to be addressed the morphological and physicochemical properties of the membrane, the optimal density of immobilized cells, the interaction of cells with the membrane, the differentiation of cells as well as the maintenance of viability and... 

Reininger-Mack A, Thielecke H, Robitzki AA. 3D-biohybrid systems applications in drug screening. Trends Biotechnol. 2002 20 56-61. 

De Bartolo, L., MoreUi, S., Rende, M., Gordano, A., and Drioh, E., New modified polyetheretherketone membrane for liver cell culture in biohybrid systems Adhesion and specific functions of isolated hepatocytes. Biomaterials, 25, 3621, 2004. 

The development of artificial organs and biohybrid systems has been significantly influenced by three core areas in nanotechnology and bionanotechnology [24] ... 

Chang, C.C., Boland, E.D., Williams, S.K., Ho3nng, J.B., 2011. Direct-write bioprinting three-dimensional biohybrid systems for future regenerative therapies. J. Biomed. Mater. Res. B Appl. Biomater. 98, 160—170. 

StiegUtz T, Ruf HH, Gross M (2002) A biohybrid system to interface peripheral nerves after traumatic lesions Design of a high channel sieve electrode. Biosensors and Bioelectroitics 17 685-696. 

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