Biodegradable polyanhydride

Mathiowitz, E., Leong, K., and Langer, R., Macromolecular drug release from biodegradable polyanhydride microspheres, 12th Int. Symp. Control. Rel. Bioact. Mater., 183-184, 1985. 

L Shieh, J Tamada, Y Tabata, A Domb, R Langer. Drug release from a new family of biodegradable polyanhydrides. J Controlled Release 29 73-82, 1994. 

Vogel BM, Cabral IT, Eidelman N, Narasimhan B, Mallapragada SK (2005) Parallel synthesis and high throughput dissolution testing of biodegradable polyanhydride copolymers. J Comb Chem 7 921-928... 

Shieh L, Tamada J, Chen I, Pang J, Domb A, Langer R. Erosion of a new family of biodegradable polyanhydrides. J Biomed Mater Res 1994 28 1465-1475. 

Gliadel is a biodegradable polyanhydride implant composed of poly[bis(p-carboxyphenoxy) propane sebacic acid] in a 20 80 monomer ratio, for the delivery of carmustine. The implant is indicated in the treatment of recurrent glioblastoma multiforme (GBM) which is the most common and fatal type of brain cancer. 

Kipper, M. J., Wilson, J. H., Wannemuehler, M. J., and Narasimhan, B. (2006), Single dose vaccine based on biodegradable polyanhydride microspheres can modulate immune response mechanism,/. Biomed. Mater. Res. Part A, 76,798-810. 

Domb, A.J. Ehrenfreund, T. Golenser, J. Langer, R. Israel, Z. Biodegradable polyanhydrides synthesis and drug delivery applications. Biodegrad. Polym. 2003,2, 121-151. 

Berkland C, Kipper MJ, Narasimhan B, et al. Microsphere size, precipitation kinetics and drag distribution control drag release from biodegradable polyanhydride microspheres. J Control Release 2004 94(1) 129-141. 

This chapter explores the development of biodegradable polyanhydride polymers as a local chemotherapeutic delivery system in brain tumor patients. In so doing, the authors detail the unique pharmacokinetic considerations inherent in CNS drug delivery, and the resultant advantages of local administration. Subsequent sections chronicle the development of biocompatible technologies, preclinical and clinical experience with polymer-based tumor treatments, and potential future advancements in local antineoplastic drug delivery. 

M.J. Kipper, J.H. Wilson, M.J. Wannemuehler, B. Narasimhan, Single dose vaccine based on biodegradable polyanhydride microspheres... 

B.M. Vogel, S.K. Mallapragada, Synthesis of novel biodegradable polyanhydrides containing aromatic and glycol functionality for tailoring of hydrophilicity in controlled dmg delivery devices. Biomaterials 26 (2005) 721-728. 

D. Hepatocyte transplantation Our initial polymer design was that of a small wafer of biodegradable polyanhydride. Hepatocytes were seeded in a monolayer onto the wafer in culture and then placed into the recipient animal while on the disc. We found that the cell number and cell density were inadequate for reliable successful engraftment when using this polymer design. Our preliminary studies indicated that for adequate hepatic function, we would need to implant at least 10% of the number of cells found in a normal liver(28). We... 

Leong, K.W., Brott, B.C., Danger, R., 1985. Biodegradable polyanhydrides as drug carrier matrices. Characterization, degradation and release characteristics. Journal of Biomedical Materials Research 19, 941—955. 

Mader, K., Nitschke, S., Stosser, R., Hans-Hubert, and Domb, A.J. (1996d) Nondestractive and localized assessment of acidic microenrironments inside biodegradable polyanhydrides by spectral spatial Electron Paramagnetic Resonance Imaging. Polymer, in press. 

E. S. Park, M. Maniar, and J.C. Shah, Biodegradable polyanhydride devices of cefazolin sodium, bupivacaine, and taxol for local drug delivery Preparation, and kinetics and mechanism of in vitro release,/. Control. Release Off. J. Control. Release Soc., 52 (1-2), 179-189,1998. 

Dang, W. and Saltzman, W.M., Controlled release of macromolecules from a biodegradable polyanhydride matrix. J. Biomater. Sci., Polym. Ed., 1994,6 291-311. 

A biodegradable polyanhydride has been prepared by polycondensation of a lithocholic acid dimer (Scheme 11b). The homopolymer has a Tg of 85°C and a melting point of >250°C, both of which can be lowered by the incorporation of a comonomer (sebacic acid). The polymers have been subjected to degradation and release studies, using p-nitroanUine as the model drug. The degradation and release rates are found to be dependent on the copolymer composition, and no apparent toxicity is observed in vivo [110]. 

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