Biochemical mechanisms signals

Phytochemicals have little nutritional value and do not get absorbed in the body, but they seem to turn on certain switches in the biochemical mechanisms, which signal the beneficial pathways to maintain health, and to turn off the switches which proceed to adverse biochemical pathways. Rice bran products have demonstrated significant benefits as nutritional therapies in diabetes, hyperlipidemia, cancer, fatty liver, hypercalcuria and heart disease. There is experimental and clinical evidence for the beneficial health effects of the following bioactives of rice bran ... 

Althot Coronins (and particularly Coronin 1C (Coronin 3)) have been implicated in disease states, much work remains to establish functional links between transcriptional regulation and phenotypic change. One important area that will require more work is the careful delineation of the Coronin 1C promoter and its immediate upstream inputs. In addition, the biochemical mechanism of Coronin 1C activity needs to be more precisely determined and the relevant binding partners necessary for this activity need to be identified. Understanding these issues may be important for revealing how diverse signaling cascades are dis-regulated in invasive/metastatic cancer. Another... 

In a linear chemical reaction system, there is a unique steady state determined by the chemical constraints that establish the NESS. For nonlinear reactions, however, there can be multiple steady states [6]. A network comprised of many nonlinear reactions can have many steady states consistent with a given set of chemical constraints. This fact leads to the suggestion that a specific stable cellular phenotypic state can result from a specific NESS in which the steady operation of metabolic reactions maintains a balance of cellular components and products with the expenditure of biochemical energy [4]. Similarly, the network of chemical and mechanical signals that regulate the metabolic network must also be in a steady state. Important problems, then, are to determine the variety of steady states available to a system under a given set of chemical constraints and the mechanisms by which cells undergo... 

Although the exact biochemical mechanism of toxicity has not been identified for toluene, it is known that the primary toxic effect of toluene is dysfunction of the brain and central nervous system (CNS-nar-cosis). The main function of neurons is to conduct electrochemical signals to one, several, or thousands of other cells. The normal physiology of these neurons is, in turn, largely dependent on the integrity of the cell membrane, which polarizes and depolarizes during the transmission of these signals. Thus, the most probable mechanism of toxicity is the unique... 

Biochemical mechanism Elevated parathyroid hormone level acts by binding its 7-helix plasma membrane receptor to activate the adenylate cyclase/protein kinase A signaling system. 

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