Bioactive antimicrobial effects

Mariscal, A., Lopez-Gigosos, R.M., Camero-Var, M.B., Femandez-Crehuet, J.B., 2011. Antimicrobial effect of medical textiles containing bioactive fibres. European Journal of Clinical Microbiology and Infectious Diseases 30 (Issue 2), 227—232. 

Takala, P.N., Salmieri, S., Boumail, A., Khan, R.A., Dang, V.K., Chauve, G., Bouchard, J., and Lacroix, M. 2013. Antimicrobial effect and physicochemical properties of bioactive trilayer polycaprolactone/ methylcellulose-based films on the growth of foodborne pathogens and total microbiota in fresh broccoli. J. Food Eng. 116 648-655. 

Gilbert J, Senyuva HZ (2008) Bioactive compounds in foods. Blackwell Publishing, Oxford Goncagul G, Ayaz E (2010) Antimicrobial effect of garlic (Allium sativum). Recent Pat Antiinfect Drug Discov 5 1-3... 

I 6 Nanoscale Bioactive Silicate Classes in Biomedical Applications 6.3.3.2 Antimicrobial Effects... 

For example, sol-gel immobilised bioactive liquids such as cineol, camphor, menthol, evening primrose and perilla oil used to functionalise textiles afford either skin-friendly textiles with antimicrobial and antiallergic effects due to immobilised natural oils or textiles for therapeutic treatment of the respiratory tract by means of immobilised mixtures of high volatility natural agents such as eucalyptol, camphor and menthol.27... 

A diversity of biological effects are possessed by benzofused six-membered heterocycles. These range from antimicrobial activity to cardiovascular, CNS, and inflammation-influencing agents. It can be inferred that the ring system itself is primarily a molecular scaffold upon which to assemble the characteristic pharmacophore for the various receptors involved. It is interesting also to note that the range of bioactivities involved differ substantially from those seen with the benzofused five-membered heterocycles described in Chapter 10. 

The occurrence in the olive pomace of unique oleuropein oligomers (14) with a degree of polymerization of up to five oleuropein monomers was reported by Cardoso et al. [27]. Their bioactivities have, however, not yet been studied. In fact, besides the evidence that olive phenolic compounds can have antioxidant, cardioprotective, antimicrobial, antihypertensive, anti-inflammatory, and chemo-preventive properties [26], the majority of the studies have focused on hydroxytyrosol (15). This compound has revealed remarkable pharmacological and antioxidant activities and thus has been further studied for its bioavaUability and metabolism in humans in order to establish its health-beneficial effects [29-31]. 

Important antimicrobial activity is also described for phloroglucinol derivatives other than hyperforin. Thus, some of the phloroglucinols isolated from H. japonicum [55] have been assayed against Gram-positive bacteria and found to be particularly effective against S. aureus. The presence of a benzoyl group on the filicinic acid moiety, typical of their structure, seems to be essential for their bioactivity. 

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