Binding site classification

Gompounds that inhibit Akt-1 are of increasing interest as possible oncology therapeutics [59]. Akt-1 is a multi-domain protein that is known to be activated after binding of its pleckstrin homology (PH) domain to its endogenous target. A report from researchers at Merck indicates that their Akt-1 inhibitor does 

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Macropolycyclic ligands, 2,942 classification, 2,917 metal complexes binding sites, 2, 922 cavity size, 2,924 chirality, 2, 924 conformation, 2,923 dimensionality, 2, 924 electronic effects, 2, 922 shaping groups, 2,923 structural effects, 2,922 molecular cation complexes, 2,947 molecular neutral complexes, 2,952 multidentate, 2,915-953 nomenclature, 2,920 Macro tetrolide actins metal complexes, 2,973 Macrotricycles anionic complexes, 2,951 cylindrical... 

Lembi CA (2003) Control of nuisance algae. In Wehr JD, Sheath RG (eds) Freshwater algae of North America ecology and classification. Academic, San Diego, CA, pp 805-834 Lipkin GM, Fozzard HA (1994) A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel. Biophys J 66 1-13... 

Brakoulias A, Jackson RM (2004) Towards a structural classification of phosphate binding sites in protein-nucleotide complexes an automated all-against-all structural comparison using geometric matching. Proteins Struct Funct Bioinformatics 56 250-260... 

Naumann, T. and Matter, H. (2002) Structural classification of protein kinases using 3d molecular interaction field analysis of their ligand binding sites Target family landscapes../. Med. Chem. 45, 2366-2378. 

Each PIR entry consists of Entry (entry ID), Title, Alternate names, Organism, Date, Accession (accession number), Reference, Function (description of protein function), Comment (e.g., enzyme specificity and reaction, etc.), Classification (superfamily), Keywords (e.g., dimer, alcohol metabolism, metalloprotein, etc.), Feature (lists of sequence positions for disulfide bonds, active site and binding site amino acid residues, etc.), Summary (number of amino acids and the molecular weight), and Sequence (in PIR format, Chapter 4). In addition, links to PDB, KEGG, BRENDA, WIT, alignments, and iProClass are provided. 

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