Bethanechol

Abdominal cramps or discomfort, colicky pain, nausea and belching, diarrhea, borbor ygmi, salivation 

Fall in blood pressure with reflex tachycardia, vasomotor response 

Flushing producing a feeling of warmth, sensation of heat around the face, sweating 

Useful for some diabetic patients with neurogenic bladder dysfunction. 

Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, diazepam,dicumarofdisulfiram,estrogens, H -antagonists, halothane, isoniazid, methylphenidate, phenothiazines, phenylbutazone, salicylates, succinimides, sulfonamides, tolbutamide, trazodone 

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When Hie cholinesterase inhibitors are administered with the anticholinergic drugp, there is a potential decrease in activity of the anticholinergic drug. There is an increased risk of toxicity of theophylline when the cholinesterase inhibitors are administered with tacrine There is a synergistic effect when tacrine is administered with succinyl-choline, cholinesterase inhibitors, or cholinergic agonists (eg, bethanechol). 

C3H< N 75-50-3) see Acetylcholine chloride Betaine hydrate Bethanechol chloride Carbachol Carnitine Cetrimonium bromide Choline chloride Choline hydroxide Decamethonium bromide Hexcarbacholine bromide Miltefosine Prolonium iodide... 

The memory deficits characteristic of Alzheimer s disease have not yet been successfully treated. There is reason to believe that potent acetylcholinesterase-resistant cholinomimetics might be effective in treating these deficits, but systemic administration of agents of this type, such as bethanechol, does not adequately deliver such... 

FIGURE 10 Effect of bethanechol on memory in lesioned rats. Be-thanechol was released from PCPP-SA 50 50 implanted intracerebrally in rats. The effect of the bethanechol released on the performance of lesioned rats in a radial maze test was performed as described in the text. 

Satoh, Y., Ishikawa, K., Oomori, Y., Takeda, S. and Ono, K. (1992) Bethanechol and a G-protein activator, NaF/AlC13, induce secretory response in Paneth cells of mouse intestine. Cell and Tissue Research 269, 213-220. 

Erdmann et al. (2000) report the fabrication of devices for the localized delivery of salicylic acid from the poly(anhydride-co-ester)s mentioned in Section II.C. A unique feature of this drug delivery system is that the drug compound is part of the polymer backbone. Devices were implanted intraorally and histopathology was reported (Erdmann et al., 2000). Chasin et al. (1990) review fabrication and testing of implantable formulations for other drugs including angiogenesis inhibitors for treatment of carcinomas and bethanechol for the treatment of Alzheimer s disease. 

Malagelada JR, Rees WD, Mazzotta LJ, Go VL Gastric motor abnormalities in diabetic and postvagotomy gastroparesis Effect of metoclopramide and bethanechol. Gastroenterology 1980 78 286-293. 

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