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Beta-blocker timolol

Answer A. Mydriasis and fixed far vision can be due to either muscarinic receptor antagonists or ganglionic blockade. Because no M blockers are listed, the correct answer is mecamylamine. Alpha agonists (phenylephrine) have no effects on the focus of the eye. The cholinesterase inhibitor (neostigmine) and alpha blocker (phentolamine) cause miosis. Ocular effects of the beta blocker (timolol) are restricted to decreased formation of aqueous humor by the ciliary epithelium. [Pg.79]

Beta-blockers Timolol, betaxolol Reduce aqueous humour production Treatment of glaucoma Eye-drop solution, suspension, gelforming solution... [Pg.460]

Beta-blockers Timolol, betaxolol, carteolol, levobunolol, metipranolol Decreased aqueous secretion from the ciliary epithelium Topical drops... [Pg.92]

Hyaluronic acid is a linear polysaccharide found in the highest concentrations in soft connective tissues where it fills an important structural role in the organization of the extracellular matrix (23,24). It has been used in ophthalmic preparations to enhance ocular absorption of timolol, a beta blocker used for the treatment of glaucoma (25), and in a viscoelastic tear formulation for conjunctivitis (26). The covalent binding of adriamycin and daunomycin to sodium hy-aluronate to produce water-soluble conjugates was recently reported (27). [Pg.233]

Timolol (Blocadren) Beta-blocker Tioconazole (Vagistat) Antifungal Tirofiban (Aggrastat) Antiplatelet... [Pg.55]

Codeine, dextromethorphan, haloperidol, thioridazine, perphenazine, nortriptyline, desipramine, fluoxetine, norfluoxetine, TCAs (hydroxylation), beta-blockers such as timolol and metoprolol, type 1C antiarrhythmics encainide, flecainide TCAs (desmethylation), triazolam, alprazolam, midazolam, carbamazepine, terfenadine, quinidine, lidocaine, erythromycin, cyclosporin... [Pg.89]

Antiarrhythmics encainide, flecainide, mexiletine Beta-blockers alprenolol, metoprolol, propranolol, timolol Opiates codeine, dextromethorphan, ethylmorphine... [Pg.93]

Pilocarpine is classified as a tertiary amine that has parasympathomimetic activity. When administered as eye drops, it causes pupillary constriction or miosis and is therefore indicated in the treatment of glaucoma. In glaucoma, multiple-drug therapy may be necessary to achieve the desired intraocular control. Pilocarpine may be used in combination with topical beta-blockers such as timolol. [Pg.335]

Timolol, Ophthalmic (Timoptic) [Antiglaucoma Agent/Beta Blocker] Uses Glaucoma Action BB Dose 0.25% 1 gt bid T to daily when controlled use 0.5% if needed 1 gtt/d gel Caution [C (1st tri D 2nd or 3rd), /+] Disp Sohi, gel SE Local irritation Interactions See Timolol EMS See Timolol OD Unlikely from ophthalmic form... [Pg.304]

Certain beta blockers have been shown to have an antimigraine effect, including propranolol, timolol, metroprolol, and atenolol. The beneficial effect appears to be comparable for the different drugs and independent of selective beta receptor blockage. [Pg.699]

Timolol CBlocadren). This nonselective beta blocker is administered orally for the treatment of hypertension and prevention of myocardial reinfarction. It may also be used to treat angina or prevent vascular headaches. [Pg.283]

Individual beta blockers are presented in Chapter 20. Beta blockers shown to be effective in treating arrhythmias include acebutolol, atenolol, esmolol, metoprolol, nadolol, propranolol, sotalol, and timolol (see Table 23-2). Choice of a specific beta blocker depends to a large extent on the exact type of arrhythmia present and the individual patient s response to the drug. [Pg.326]

With some drugs that are delivered via eye drops, some systemic absorption can occur which in turn can cause systemic side-effects. For example, timolol (a beta-blocker) can worsen or precipitate bronchospasm in asthmatic and COPD patients. [Pg.292]

Systemic absorption may occur when eye drops containing beta-blockers are administered. Beta-receptors are found in heart muscle (predominantly beta-1) and the smooth muscle of the blood vessels and bronchioles (mainly beta-2). Selective beta-blockers (atenolol, bisoprolol, metoprolol, nebivolol, acebutolol) primarily (but not exclusively) antagonize beta-1 receptors, while the non-selective drugs (carvedilol, celiprolol, esmolol, labetalol, nadolol, oxprenolol, pindolol, propanolol, sotalol, timolol) block both beta-1 and beta-2 receptors,... [Pg.2]

FLECAINIDE BETA-BLOCKERS Risk of bradycardia (occasionally severe), 1 BP and heart failure. Note, a single case report has described bradycardia when timolol eye drops given to a patient on flecainide Additive negative inotropic and chronotropic effects Monitor PR, BP and ECG closely watch for development of heart failure... [Pg.21]

BETA-BLOCKERS ANAESTHETICS-GENERAL Risk of severe hypotensive episodes during induction of anaesthesia (including patients using timolol eye drops) Most general anaesthetics are myocardial depressants and vasodilators, so additive 1 BP may occur Monitor BP closely, especially during induction of anaesthesia... [Pg.63]

BETA-BLOCKERS OPIOIDS 1. Risk of t plasma concentrations and effects of labetalol, metoprolol and propranolol t systemic effects of timolol eye drops 2. t plasma concentrations of esmolol when morphine is added 3. t plasma concentrations of metoprolol and propranolol when dextro-propoxyphene is added 1. Methadone inhibits CYP2D6, which metabolizes these beta-blockers 2. Unknown 3. i hepatic clearance of metoprolol and propanolol 1. Monitor BP at least weekly until stable 2. Monitor BP closely 3. Monitor BP at least weekly until stable. Warn patients to report symptoms of hypotension (lightheadedness, dizziness on standing, etc.)... [Pg.65]

BETA-BLOCKERS CYTOTOXICS Imatinib may cause an t in plasma concentrations of metoprolol, propanolol and timolol, with a risk of toxic effects Imatinib is a potent inhibitor of CYP2D6 isoenzymes, which metabolize beta-blockers Monitor for clinical efficacy and toxicity of beta-adrenergic blockers... [Pg.66]

BETA-BLOCKERS VENLAFAXINE T plasma concentrations and efficacy of metoprolol, propranolol and timolol Venlafaxine inhibits CYP2D6-mediated metabolism of metoprolol, propanolol and timolol Monitor PR and BP at least weekly watch for metoprolol toxicity (in particular, toss of its cardioselectivity) and propanolol toxicity... [Pg.68]

BETA-BLOCKERS BARBITURATES Regular barbiturate use may t elimination of those beta-blockers metabolized by the liver (metoprolol, propanolol, timolol) Barbiturates induce CYP1A2-, CYP2C9- and CYP2C19-mediated metabolism of propanolol Monitor BP at least weekly until stable and watch for t BP... [Pg.69]

BETA-BLOCKERS QUININE Risk oft plasma concentrations and effects of labetalol, metoprolol and propranolol t systemic effects of timolol eye drops Quinine inhibits CYP2D6, which metabolizes these beta-blockers Monitor BP at least weekly until stable... [Pg.71]

BETA-BLOCKERS RITONAVIR, TIPRANAVIR t adverse effects of carvedilol, metoprolol, propanolol and timolol Inhibition of CYP2D6-mediated metabolism of these beta-blockers and CYP2C19-mediated metabolism of propanolol Use an alternative beta-blocker if possible if not, monitor closely... [Pg.72]

BETA-BLOCKERS DRUG DEPENDENCE THERAPIES - BUPROPION t plasma concentrations of metoprolol, propranolol and timolol, with risk of toxic effects Bupropion and its metabolite hydroxybupropion inhibit CYP2D6 Initiate therapy of these drugs at the lowest effective dose... [Pg.74]

IMATINIB 1. ANTIARRHYTHMICS -flecainide, mexiletine, propafenone 2. ANTIDEPRESSANTS - fluoxetine, paroxetine, TCAs, trazodone, venlafaxine 3. ANTIPSYCHOTICS -clozapine, haloperidol, perphenazine, risperidone, thioridazine 4. BETA-BLOCKERS - metoprolol, propanolol, timolol 5. DONEPEZIL 6. METHAMPHETAMINE Imatinib may cause t plasma concentrations of these drugs, with a risk of toxic effects Inhibition of CYP2D6-mediated metabolism of these drugs Watch for early features of toxicity of these drugs... [Pg.312]

See other pages where Beta-blocker timolol is mentioned: [Pg.1160]    [Pg.1160]    [Pg.628]    [Pg.128]    [Pg.19]    [Pg.1218]    [Pg.90]    [Pg.303]    [Pg.463]    [Pg.319]    [Pg.89]    [Pg.71]    [Pg.65]    [Pg.69]    [Pg.211]    [Pg.280]    [Pg.411]   
See also in sourсe #XX -- [ Pg.145 , Pg.146 , Pg.146 , Pg.147 , Pg.148 , Pg.148 , Pg.149 , Pg.149 ]



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