5-Chloro-2- benzophenone

Preparation of 2-Cyc/opropy/methy/amino-5-Ch/orobenzophenone To a solution of 315 g (1.09 mols) of 2-cyclopropylmethylamino-5-chloroDenzhydrol in 4 liters of benzene is added 453.6 g (5.22 mols) of manganese dioxide, freshly prepared according to the method of Attenburrow et al, J.C.S. 1952, 1104. The mixture is then refluxed for VA hours, filtered, and the filtrate evaporated under vacuum. The reddish residue is recrystallized from 510 ml of 90% acetone-10% water, giving 181 g of pure 2-cyclopropylmethylamino-5-chloro-benzophenone, MP 79° to 80°C (58% yield). Upon concentration of the mother liquor a second crop of 2-cyclopropylmethylamino-5-chlorobenzophenone weighing 34.1 g and melting at 76.5°-78°C are obtained. 

Fluoro 6 chloro acetophenone see 2 Fluoro phenacyl chloride 4 Fluoro 2 chloro benzophenone see 2 Chloro phenyl 4 fluoro phenyl ketone Fluoro dichloro methyl sulfenyl chloride dichlorofluanid... 

Diazepam may be prepared by the reaction scheme shown in Figure 6 with the reaction of 2-methylamino-5-chloro-benzophenone and ethyl glycinate to form diazepam11. 

It may be prepared by the diazotization and subsequent treatment with sulphur dioxide in glacial acetic acid in the presence of cupric chloride of 3-amino-4-chloro-benzophenone-2-carboxylic acid to yield 4-chloro-2 -carboxy-benzophenone-3-sulphonyl chloride. This on treatment with thionyl chloride followed by amidation in aqueous ethanol and finally with HCl gives crude chlortalidone which is recrystallized from aqeous ethanol. 

How would you synthesize chlorthalidone, a sulphonamide diuretic, from 3-amino-4-chloro benzophenone-2-carboxylic acid ... 

The best photo-crosslinking initiator for PE is 1,2,3,4,5,8-hexachloronaphthalene XPE obtained by means of 4-chloro-benzophenone and triallylcya-nurate has improved homogeneity of crosslinking [17]. The typical conditions are 150-180°C for 10-15 min. 

Also obtained by degradation of 6-chloro-2,3-diphenylbenzofuran with chro-minm trioxide in boiling acetic acid during 40 min or 2 h, followed by saponification of the 2-benzoyloxy-4-chloro-benzophenone so formed with 2 N or 4 N sodium hydroxide in refluxing aqueous ethanol for 1 h or 15 min [44,515]. Preparation by reaction of 4-chloro-2-methoxybenzoyl chloride (SM) with benzene in the presence of aluminium chloride at r.t. [6] according to [14]. SM was obtained from 2-amino-4-chlorotoluene by a four-step synthesis. 

Preparation from 2-chlorothioxanthen-9-one 10,10-dioxide (SM) by a three-step synthesis SM by refluxing in a solution of 2% sodium hydroxide in dioxane/water mixture (65 35) for 4 h gave the 2-(2-hydroxy-5-chlorobenzoyl) phenylsulfmic acid (37%). The former, by reaction with mercuric chloride in refluxing aqueous acetic acid for 4 h, led to the 2-chloromercuri-2 -hydroxy-5 -chloro-benzophenone (74%). Removal of the chloromercury group was achieved with concentrated hydrochloric acid in refluxing ethanol for 2 h (84%) [62],... 

Propiophcnone Benzyl methyl ketone Benzyl ethyl, Benzophenone. p Chloro- ... 

Photolysis in concentrated HCl of 3,5-diphenyl-2,l-benzisoxazole gave 2-amino-3-chloro-5-phenylbenzophenone and 2-amino-5-(p-chlorophenyl)benzophenone via similar intermediates (Scheme 20) (71HCA2111). 

Chloro-5-nitrobenzaldehyde, -acetophenone, or -benzophenone derivatives treated with 2-aminothiophenol under alkaline conditions provided good yields of the corresponding dibenzo[(3,/][l,4]thiepins. Similar treatment of 2-chloro-3,5-dinitrobenzophenone (318) provided 58% of dibenzo[(3,/][l,4]thiepin 321 and 20% of phenothiazine 323. Its formation can be easily explain by the Smiles rearrangement of the initially formed intermediate 320 into diphenylamine derivative 322, followed by denitrocyclization reaction leading to the corresponding product of denitrocyclization 323 (Scheme 49). When the reaction was done in pyridine, only this product was isolated in 50% yield (57JCS3818). 

Chloro-1 -methyl-6-phenyl4H-s-triazolo-[4,3-a] [1,4] -benzodiazepine A stirred suspension of 5-chloro-2-[3-(bromomethyl)-5-methyl4H-1,2,4-triazol4-yl] -benzophenone (391 mg, 0.001 mol) in tetrahydrofuran (15 ml) was cooled in an ice-bat hand treated with a saturated solution of ammonia in methanol (12.5 ml). The resulting solution was allowed to warm to ambient temperature and stand for 24 hours. It was then concentrated in vacuo. The residue was suspended in water, treated with a little sodium bicarbonate and extracted with methylene chloride. The extract was washed with brine, dried with anhydrous potassium carbonate and concentrated. The residue was crystallized from methylene chloride-ethyl acetate to give... 

Methylimidazole HCI 2-Amino-5-chloro-2 -fluoro-benzophenone Ethyl aminomalonate hydrochloride... 

A) 1-(2-Amino-5-chlorophenyll-1-(2-fluorophenyll-2-a2a-but-1-en-4-ol A mixture of 40 g of 2-methylimidazole hydrochloride and of 90 g of 2-amino-5-chloro-2 -fluoro-benzophenone in 240 ml of ethanolamine is heated at 135 for 2 hours. After cooling, the reaction mixture is poured into an aqueous sodium bicarbonate solution. The mixture is extracted with ether, the organic phase is washed repeatedly with water and is dried over sodium sulfate, and the solvent is evaporated to dryness. The residual oil is chromatographed on a silica column, elution being carried out with a 50/50 mixture of cyclohexane and ethyl acetate. 

Sodium methoxide (1.2 g) in dimethylformamide (150 ml) was stirred with 3,5-dim ethoxy-4 reaction mixture was then treated with /3-morpholinoethyl chloride (3.4 g) and heated for 1 hour at 140°C, then evaporated to dryness, and treated with water to give a solid material. The mixture was filtered, washed and crystallized from cyclohexane to give 3,5-di-methoxv-4 -chloro-4-( morpholinoethoxy)-benzophenone (6.5 g), MP 91°C to 92°C. The product was then reacted at about 0°C with gaseous hydrogen chloride in ether to give, after crystallization from isopropanol, the corresponding hydrochloride which hada MPof 187.9°C. 

A mixture of 5-chloro-2-[chloroacetyl(mcthyl)amino]benzophenone (1.136 g, 3.1 mmol), hexamethylenetetramine (1.0 g, 7 mmol) and EtOH (15 mL) was heated under reflux for 10 h. The solvent was distilled off under reduced pressure, H20 (10 mL) was added to the residue and the mixture was extracted with benzene (3 x 10 mL). The combined extracts were washed with H20, dried (Na2S04) and evaporated in vacuo. Crystallization the residue (Et2Q) gave the product yield 0.79g (80%) mp 128-130 C. 

I-demethyl-derivative from 5-chloro-2-(2,3-dioxopiperazino)benzophenone ... 

C25H27CIO3 /O/Oy-i -J) see Trenbolone acetate ( )-2-chioro-3-[4-[(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)incthoxy]phenyl]propionic acid (C23H27C10 97322-69-5) sec Troglitazone 4 -chloro-2 (24midazoUn-2-yl)benzophenone (Ci HjiClNjO 22590-J7-6) see Mazindo ... 

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