3- Methoxy benzoic acid

D-AniMC acid (8) Benzoic acid, 2-methoxy- (9) (579-75-9) l-Bmnioheptanc Heptane, 1-bromo- (8, 9) (629-04-9) ( yclt)hcxdnc-1,3-dionc 1,3-Cyclohexanedione (8, 9) (504-02-9)... 

Synonyms 2-Anisic acid o-Anisyl acid Benzoic acid, 2-methoxy 2-Methoxybenzoic acid o-Methoxybenzoic acid... 

Benzoic acid, 2-methoxy. See o-Anisic acid Benzoic acid, 4-methoxy. See p-Anisic acid Benzoic acid, 2-methoxy-, ethyl ester. See Ethyl o-anisate... 

CAS 606-45-1 EINECS/ELINCS 210-118-6 Synonyms o-Anisic acid, methyl ester Benzoic acid, 2-methoxy-, methyl ester Dimethyl salicylate 2-Methoxybenzoic acid methyl ester o-Methoxybenzoic acid methyl ester o-Methoxy methyl benzoate Methyl 2-methoxybenzoate Methyl o-methoxybenzoate Methyl salicylate o-methyl ester Empirical C9H10O3... 

Synonyms o-Anisic acid, methyl ester Benzoic acid, 2-methoxy-, methyl ester Dimethyl salicylate o-Methoxybenzoic acid methyl ester o-M ethoxy methyl benzoate Methyl o-anisate Methyl 2-methoxybenzoate Methylsalicylate methyl ester Empiricai C9H10O3 Formuia CH3OC6H4CO2CH3 Properties M.w. 166.18 dens. 1.157 b.p. 248 C flash pt. > 230 F ref. index 1.5340 Toxicology LD50 (oral, rat) 3800 mg/kg, (skin, rabbit) > 5 g/kg mod. toxic by ing. si. toxic by skin contact TSCA listed Hazardous Decomp. Prods. Heated to decomp., emits acrid smoke and irritating vapors Uses Synthetic flavoring agent in foods and pharmaceuticals... 

CioHnIO 3 4-iodo-benzoic acid 2-methoxy-ethyl ester ... 

Benzoic acid, /(-chloro-Benzoic acid, m-hydroxy-Benzoic acid, o-hydroxy-Benzoic acid, p-hydroxy-Benzoic acid, mercapto-Benzoic acid, methoxy-Benzoic acid, methyl-Benzoic acid, o-, m-, and... 

An important question about the mechanism of acid catalyzed esterification concerns the origin of the alkoxy oxygen For example does the methoxy oxygen m methyl benzoate come from methanol or is it derived from benzoic acid s... 

Benzoic acid-3,6-dichloro-2-methoxy-2-ethoxy-l-methyl-2-oxoethyl ester [87214-73-1]... 

Pyrogallol monomethyl ether has been prepared by the methylation of pyrogallol with dimethyl sulfate or methyl iodide by the decarboxylation of 2,3-dihj droxy-4-methoxy-benzoic acid and by the methylation of pyrogallol carbonate with diazomethane and subsequent hydrolysis. The method described is taken from the improved procedure of Baker and Savage for the preparation of pyrogallol monomethyl ether from o-vanillin by oxidation with hydrogen peroxide. 

Anisic acid is p-methoxy-benzoic acid, C, H. COCHg. COOH.. It is found in aniseed oil, and also in Tahiti vanillas. It is a crystalline body-melting at 184°. 

Anethole, C H O, a major constituent of the oil of anise, has the lH NMR spectrum shown. On oxidation with Na2Cr207, anethole yields p-methoxy-benzoic acid. What is the structure of anethole Assign all peaks in the NMR spectrum, and account for the observed splitting patterns. 

Anisic acid, methyl ester [Benzoic acid, 4-methoxy-, methyl ester], 55, 40, 41 o-Amsidine [Benzenamine, 2-methoxy-], p-bromination of, 55, 23 [10] ANNULFNE, [ 1 l-Oxablcyclo[4 4 1]-undeca-l,3,5,7,9-pentaene], 55, 86 Anthramhc acid [Benzoic acid, 2-amino-], p-brominahon of, 55, 23 Apparatus, distillation of benzocyclopro-pene for, 55,13... 

Benzoic acid, tert-butyl ester [Benzoic acid, 1,1-dimethylethyl ester], as impunty in ferf-butyUithium, 55, 125 Benzoic acid, 4-methoxy-, methyl ester, 55, 40... 

CN (25-cij)-benzoic acid [l-[4-[(3-amino-2,3,6-trideoxy-a-L-/>>xt>-hexopyranosyl)oxy]-l,2,3,4,6,l I-hexahydro-2,5,12-lrihydroxy-7-methoxy-6,1 l-dioxo-2-naphthacenyl]ethylidene]hydrazide... 

C,2oH2iiN20 61380-02-7) see Alfentanil iV-(4-methoxymethyl-4-piperidyl)propionaniIide (C15H24N2O2 61086-18-8) see Alfentanil Sufentanil 2-methoxy-5-(methylsulfonyl)benzoic acid (CgHioOjS 50390-76-6) see Tiapride 2-methoxy-10-[2-methyl-3-(p-toluenesulfonyloxy)propyi]-phenothiazine... 

All cements that contain eugenol inhibit the polymerization of acrylates, and those of EBA-eugenol are no exception. In order to remedy this and other defects, Brauer and his coworkers examined alternatives to eugenol (Figure 9.7). These included the esters of vanillic acid (3-methoxy-4-hydroxybenzoic acid, HV) and syringic acid (3,5-dimethoxy-4-hydroxy-benzoic acid). Both are 3-methoxy-4-hydroxy compounds and are thus chemically related to eugenol and guaiacol. Both are solids and have to be dissolved in EBA where they form satisfactory cements with EBA zinc oxide powder. The vanillate (EBA-HV) cements are the more important. 

Preparation of 2 -Anilino-6 -diethylamino-3 -methylfluoran (77d). To a solution of 2-(4-diethylamino-2-hydroxybenzoyl)benzoic acid (0.1 mol) in 98% sulfuric acid (1 50 g) was added 4-methoxy-2-methyldiphenylamine (0.1 mol) in limited amounts, while the temperature was maintained to not rise above 30 °C. The resulting mixture was stirred at room temperature for 20 h, and poured into ice water (1000 ml). The precipitate was filtered off, washed with water, and then refluxed with a mixture of toluene (400 ml) and 20% aqueous sodium hydroxide (150 g) for 1 h. The toluene layer was separated, washed with hot water, and concentrated to leave ca. 100ml of toluene. The residue was then refluxed with methanol (100 ml) for 1 h. After being cooled, the precipitate is filtered off, washed with methanol, and dried to give 2 -anilino-6 -diethylamino-3 -methylfluoran in 90% yield as an off-white powder, mp 197-198 °C. 

Preparation of 6 -Diethylamino-2 -(2,4-dimethyIaniIino)-3 -methylfluoran (77e). To a solution of 2-(4-diethylamino-2-hydroxybenzoyl)benzoic acid (0.1 mol) in 98% sulfuric acid (150 g) was added 4-methoxy-2,2, 4 -trimethyldiphenylamine (0.1 mol) in limited amounts, while the temperature... 

The use of oxazolines in aromatic substitution is a valuable synthetic tool.2 The o-methoxy- or o-fluorophenyloxazoline reacts readily with a variety of organofithium or Grignard reagents to displace only the ortho substituent. In this fashion a number of ortho-substituted benzoic acids, benzaldehydes, and unsymmetrical biphenyls are accessible. The reaction takes place under very mild conditions, usually at or below room temperature, and thus allows a number of other sensitive groups to be present. 

Figure 12.12 THM GC/MS curves of a Winsor Newton lemon alkyd paint (a) and of an alkyd sample taken from Fontana s work Concetto spaziale (1961) (b). Peak assignments 1, 1,3 dimethoxy 2 propanol 2, 1,2,3 trimethoxy propane 3, 3 methoxy 1,2 propandiol 4, 4 chloro benzenamine 5, 3 methoxy 2,2 bis(methoxymethyl) 1 propanol 6, 3 chloro N methyl benzenamine 7, 3 methoxy 2 methoxymethyl 1 propanol 8, 4 chloro N methyl benzenamine 9, phthalic anhydride 10, 3 chloro 4 methoxy benzenamine 11, suberic acid dimethyl ester 12, dimethyl phthalate 13, azelaic acid dimethyl ester 14, sebacic acid dimethyl ester 15, palmitic acid methyl ester 16, oleic acid methyl ester 17, stearic acid methyl ester 18, 12 hydroxy stearic acid methyl ester 19, 12 methoxy stearic acid methyl ester 20, styrene 21, 2 (2 methoxyethoxy) ethanol 22, 1,1 oxybis(2 methoxy ethane) 23, benzoic acid methyl ester 24, adipic acid dimethyl ester 25, hexadecenoic acid methyl ester 26, dihydroisopimaric acid methyl ester 27, dehydroabietic acid methyl ester 28, 4 epidehydroabietol...

Zhao H, Jaynes WF, Vance GF (1996) Sorption of the ionizable organic compound, dicamba (3,6-dichloro-2-methoxy benzoic acid), by organoclays. Chemosphere 33 2089-2100... 

Ginkgo extract has no effect on the hepatic microsomal drug oxidation system, as measured by antipyrine elimination, even at doses of 400 mg per day (Duche et al. 1989). Ginkgo metabolites, the substituted benzoic acids (4-hydroxybenzoic acid conjugate, 4-hydroxyhippuric acid, 3-methoxy-4-hydroxyhippuric acid, 3,4-dihydroxybenzoic acid, 4-hydroxybenzoic acid, hippuric acid and 3-methoxy-4-hydroxybenzoic acid [vanillic acid]), are excreted in urine (Pietta et al. 1997). 

When substituents can also be involved in the resonance effects, changes in acidity become more marked. Consider hydroxy- and methoxy-benzoic acid derivatives. The pATa values are found to be 3.0, 4.1, and 4.6 for the ortho, meta, and para hydroxy derivatives respectively, and 4.1, 4.1, and 4.5 respectively for the corresponding methoxy derivatives. 

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