Oxidation drugs

Bertilsson, L. (1995). Geographical/interracial differences inpolymorphic drug oxidation current state of knowledge of cytochrome P450 (CYP) 2D6 and 209. Clin. Pharmacokinet., 29, 192— 209. 

J. Aranda, S. MacLeod, K. Renton, and N. Eade, Hepatic microsomal drug oxidation and electron transport in newborn infants, J. Pediatr, 85, 534 (1974). 

Shitara, Y., Li, A., Kato, Y., Itoh, T., Sato, H., Sugiyama, Y., Transporter-mediated drug-drug interaction. Abstract of 14th International symposium on microsomes and drug oxidations, July 22-26, 2002, Sapporo, Japan, Abstract No. P24-B-35. 

Baskin, L.S., and Yang, C.S. (1980b) Microsomes, Drug Oxidations, and Chemical Carcinogenesis. pp. 103-106. Academic Press, New York. 

Pohl, L.R., Martin, J.L., Taburet, A.M. and George, J.W. 1980b. Oxidative bioactivation of haloforms into hepatotoxins. In Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Vol. II. Coon, M.J., et al., Eds. Academic Press, New York. Pp. 881—884. 

An interesting aspect to CYP3A4-mediated drug oxidations is the susceptibility of the enzyme to exhibit a variety of atypical kinetic profiles including positive... 

Yamazaki, H., Suzuki, M., Tane, K., Shimada, N., Nakajima, M. and Yokoi, T. (2000) in vitro inhibitory effects of troglitazone and its metabolites on drug oxidation activities of human cytochrome P450 enzymes comparison with pioglitazone and rosiglitazone. Xenobiotica, 30 (1), 61—70. 

Bend, J.R. et al. in "Proceedings of the Third International Symposium on Microsomes and Drug Oxidations" eds. A.H. Conney et al., in press, Pergamon Press, Oxford, 1978. 

Hepatic microsomal and solubilized mixed-function oxidase systems from the little skate, Baja erinacea, a marine elasmobranch. In Ullrich, V., Hildebrandt, A., Roots, I., Eastabrook, R.W. (Eds.) Microsomes and Drug Oxidations (1976). Pergamon Press, Oxford, pp 16O-I69. 

Ginkgo extract has no effect on the hepatic microsomal drug oxidation system, as measured by antipyrine elimination, even at doses of 400 mg per day (Duche et al. 1989). Ginkgo metabolites, the substituted benzoic acids (4-hydroxybenzoic acid conjugate, 4-hydroxyhippuric acid, 3-methoxy-4-hydroxyhippuric acid, 3,4-dihydroxybenzoic acid, 4-hydroxybenzoic acid, hippuric acid and 3-methoxy-4-hydroxybenzoic acid [vanillic acid]), are excreted in urine (Pietta et al. 1997). 

Raimundo, S., Fischer, J., Eichelbaum, M., Griese, E.U., Schwab, M., Zanger, B. (2000) Elucidation of the genetic basis of the common intermediate metaboUzer phenotype for drug oxidation by CYP2D6. Pharmacogenetics, 10, 577-581. 

The next process we consider is drug metabolism. The study of oxidation reactions in compounds such as benzo (a) pyrene has emphasized the P450-dependent oxidation systems of the liver toxicologists have virtually Ignored other potentially important oxidizing systems. Future research may find drug-oxidation systems which are not P450-linked, and even other membrane-bound and non-membrane-bound oxidative and reductive systems in whole animal cells. 

P. (1986) The molecular mechanisms of two common polymorphisms of drug oxidation—evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation. Xenobiotica 16, 449-464. 

The other isoform responsible for a substantial portion (about 10%) of the CYP-mediated drug oxidation... 

Verhoeven CHJ, Vos RME, Bogaards JJP. Characterization and inhibition of human cytochrome P450 enzymes involved in the in vitro metabolism of mirtazapine. Presentation at International Symposium on Microsomes and Drug Oxidations, Los Angeles, July 21-24, 1996. 

Microsomal drug oxidations require P450, P450 reductase, NADPFI, and molecular oxygen. A simplified scheme of the... 

Baker, M., Gregerson, M. S., Martin, S. M., and Buettner, G. R. (2003), Free radical and drug oxidation products in an intensive care unit sedative Propofol with sulfite, Crit. Care Med., 31,787-792. 

Kato R, Onoda K. Studies on the regulation of the activity of drug oxidation in rat liver microsomes by androgen and estrogen. Biochem Pharmacol 1970 19 1649-1660. 

Powis G, Talcott RE, Schenkman JB. In Ullrich V, Roots A, Hildebrandt A, et al., eds. Microsomes and Drug Oxidations. Oxford Pergamon Press 137. 

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