Benzene inhalation

Cronkite. E.P., Bullis, J., Inoue, T, and Drew, R.T. (1984). Benzene inhalation produces leukemia in mice, IbxicoL AppL PharmacoL 75,358. 

Levels of Significant Exposure to Benzene - Inhalation 2-2 Levels of Significant Exposure to Benzene - Oral 2-3 Metabolic Pathways for Benzene... 

Table 2-1. Levels of Significant Exposure to Benzene - Inhalation... 

Green et al. (1981 b) examined the effect of benzene inhalation on the peripheral blood and bone marrow of CD-I mice following exposures to 0 or 9.6 ppm for 6 hours per day, 5 days per week for 10 weeks (50 days), or to 0 or 302 ppm for 6 hours per day, 5 days per week for 26 weeks. Animals exposed to... 

Other evidence of genotoxicity induced by benzene includes inhibition of DNA synthesis in certain cell types, although inhibition of DNA synthesis is not always indicative of genotoxic damage. Acute 4-hour inhalation exposure of female ICR mice to 2,000 ppm benzene produced a 15% inhibition of DNA synthesis in bone marrow cells, and exposure to 3,000 ppm inhibited DNA synthesis by 33% (Lee et al. 1988). Delayed cell cycle in mouse bone marrow and DNA adducts with benzene metabolites in mouse and rat hemoglobin or rat liver cells were also evidence of benzene inhalation exposure (Lutz and Schlatter 1977 Sabourin et al. 1990 Tice et al. 1980, 1982). Other genotoxicity studies are discussed in Section 2.5. 

Abraham N. 1996. Hematopoietic effects of benzene inhalation assessed by long term bone marrow culture. Environ Health Perspect 104 (Suppl 6) 1277-1282. 

Aoyama K. 1986. Effects of benzene inhalation on lymphocyte subpopulations and immune response in mice. Toxicol Appl Pharmacol 85 92-101. 

Cronkite EP, Bullis JE, Inoue T, et al. 1984. Benzene inhalation produces leukemia in mice. Toxicol Appl Pharmacol 75 358-361. 

Cronkite EP, Inoue T, Carsten AL, et al. 1982. Effects of benzene inhalation on murine pluripotent stem cells. J Toxicol Environ Health 9 411-421. 

Evans HL, Dempster AM, Snyder CA. 1981. Behavioral changes in mice following benzene inhalation. Neurobehav Toxicol Teratol 3 481-485. 

Green JD, Snyder CA, LoBue J, et al. 1981b. Acute and chronic dose/response effect of benzene inhalation on the peripheral blood, bone marrow, and spleen cell of CD-I male mice. Toxicol Appl Pharmacol 59 204-214. 

Magos GA, Lorenzana-Jimenez M, Vidrio H. 1990. Toluene and benzene inhalation influences on ventricular arrhythmias in the rat. Neurotoxicol Teratol 12(2) 119-124. 

Rosenthal GJ, Snyder CA. 1985. Modulation of the immune response to Listeria monocytogenes by benzene inhalation. Toxicol Appl Pharmacol 80 502-510. 

Sabourin PJ, Sun JD, Bimbaum LS, et al. 1989b. Effect of repeated benzene inhalation exposures on subsequent metabolism of benzene. Exp Pathol 37 155-157. 

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