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Benzaldehyde, 4-Amino

Barbituric acid, 32, 7 Benzaldehyde, 30,100 Benzaldehyde, amino, 31, 6 Benzamidine, N,N -diphenyl-, 31, 48 Benzanilide, 31, 48 Benzene, 31, 88 32, 10 Benzene (cHLORO-fert-BUTYL)-, 32, 90 Benzene, 2-chloro-1,3-dinitro-, 32,23 ETHYNYL-, 30, 72... [Pg.56]

Benzaldehyde, -amino, 31, 6 /I-DIMETHYLAMINO-, 33, 27 Benzaldehyde, purification of, 33, 71 Benzalmalonic acid, ethyl ester, 37, 5 4-Benzal-2-phenyl-5-oxazolone, 37, 5 Benzamidine, N,N -diphenyl-, 31, 48 N-phenyl-, 36, 64 Benzanilide, 31, 48... [Pg.94]

Diamino-4-phenylthiazole condenses with benzaldehyde, yielding 2-amino-4-pheny]-5-benzalaminothiazole (241). [Pg.47]

By condensing carbon oxysulfide with o-aminOnitriles the corresponding 2-hydroxy-5-aminothiazoles can be obtained. In the presence of benzaldehyde or its substituted derivatives the reaction leads to 5-benzy-lideneaminothiazole derivatives (218) in good yields (Scheme 114 and Table 11.35) (393, 442). However, the reaction fails with or-amino acetonitrile (206), R = H (317). The 2-alkoxy analogs (220), R = Me, Et, Pr, Bu, vinyl, were similarly obtained from 219 and benzylideneamino acetonitrile (Scheme 115a) (393). [Pg.288]

Substituted 5-hydroxythiazoles (267b), Rj = alkylmercapto, acyl-amino, and sec-amino, are prepared by cydization of N-thioacyl-amino acids (266) with phosphorus tribromide or acetic anhydride (Scheme 137) (317, 350). i en the cydization of 266, R2 = H, is carried out with acetic anhydride in the presence of benzaldehyde (317, 325) or ethylformate (317), the benzylidene (268), R2=Ph, Rj = SR or CH2Ph, or 4-ethoxymethylene (268), Rj = SR and R2 = OEt, derivative is obtained directly (Scheme 138). [Pg.303]

The acid catalyzed condensation of benzaldehydes with 2-acetyIpyridine provides access to hydroxy- or amino-indolizines (Scheme 58a) (71CB1629,71CB1645). A remarkable synthesis of fused pyrrolidines in which aldehydes also provide C-2 is exemplified in Scheme 58b... [Pg.121]

All heterocyclic enamines readily undergo condensation with o-amino-benzaldehyde. The quinoxaline derivatives thus formed have a characteristic yellow color. Therefore, this reaction can serve as evidence of the presence of an enamine in plants (295,309). [Pg.302]

In a separate report, the Darzens reaction was recently used by Barluenga, Concellon, and coworkers for the preparation of enantiopure a"-amino a,P-epoxy ketones. Accordingly, the Z enolate of a"-amino a-bromo ketone 41 was generated with KHMDS at -100°C. Benzaldehyde was added, and trans epoxyketone 42 was isolated in 87% yield and >95% de. ... [Pg.19]

Tryptophan (15) and its substituted derivatives also react with aldehydes to give l,2,3,4-tetrahydro-jS-carboline-3-carboxylic acids (17), Acetaldehyde and benzaldehyde yield the expected products with the amino acid and its A -methyl derivative (abrine). ... [Pg.85]

A series of chiral boron catalysts prepared from, e.g., N-sulfonyl a-amino acids has also been developed and used in a variety of cycloaddition reactions [18]. Corey et al. have applied the chiral (S)-tryptophan-derived oxazaborolidine-boron catalyst 11 and used it for the conversion of, e.g., benzaldehyde la to the cycloaddition product 3a by reaction with Danishefsky s diene 2a [18h]. This reaction la affords mainly the Mukaiyama aldol product 10, which, after isolation, was converted to 3a by treatment with TFA (Scheme 4.11). It was observed that no cycloaddition product was produced in the initial step, providing evidence for the two-step process. [Pg.160]

Benzaldehyde and hydroxylamine may be reacted, the product chlorinated and then reacted with cyanamid to give 5-amino-3-phenyl-1,2,4-oxadiazole. [Pg.207]

In 212 cc of water are mixed 21.2 grams (0.112 mol) of N-(benzylidene)-3-amino-2-oxa-zolidone, 8.93 grams of concentrated sulfuric acid, and 30.1 grams (0.124 mol) of 5-ni-tro-2-furaldehyde diacetate. This mixture is heated to effect the hydrolysis of N-(benzy-lidene)-3-amino-2-oxazolidone, steam distillation of the benzaldehyde and hydrolysis of 5-nitro-2-furaldehyde diacetate. Approximately IV2 hours are required for this reaction to take place. When the bulk of the benzaldehyde has been removed, 50 cc of 99% isopropanol are added, the reaction mixture is refluxed a short time, and the crystals of N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone are filtered from the hot suspension. The product is washed with water and isopropanol and dried a yield of 23.3 grams, 92.8% based on N-(benzylidene)-3-amino-2-oxazolidone of MP 254° to 256°C is obtained, according to U.S. Patent 2,759,931. [Pg.709]

Sodium azide, reaction with l butyl chloroacetate, 46, 47 reaction with diazomum salt from o amino-f> -ni trobiphcny L, 46, 86 Sodium chlorodifluoroacetate, 47, SO reaction with tnphenylphosphme and benzaldehyde, 47, SO Sodium ethoxide, 46, 2S reaction with diethyl succinate, 46,2S Sodium formate as reducing agent in preparation of palladium catalyst, 46, 90... [Pg.138]

Ethoxycarbonyl)amino]benzaldehyde oxime (2.1 g, 10 mmol) was stirred with 2M NaOH (25 mL, 50 mmol) and the mixture was heated on a steam bath until a clear solution had formed. The hot solution was made weakly acid and cooled, whereupon the product crystallized as the dihydrate mp 244 C (dec.). [Pg.442]

A very simple and elegant alternative to the use of ion-exchange columns or extraction to separate the mixture of D-amino add amide and the L-amino add has been elaborated. Addition of one equivalent of benzaldehyde (with respect to die D-amino add amide) to the enzymic hydrolysate results in the formation of a Schiff base with die D-amino add amide, which is insoluble in water and, therefore, can be easily separated. Add hydrolysis (H2SQ4, HX, HNO3, etc.) results in the formation of die D-amino add (without racemizadon). Alternatively the D-amino add amide can be hydrolysed by cell-preparations of Rhodococcus erythropolis. This biocatalyst lacks stereoselectivity. This option is very useful for amino adds which are highly soluble in die neutralised reaction mixture obtained after acid hydrolysis of the amide. [Pg.279]

Process economics dictate the recycling of the unwanted isomer. Path A in Figure A8.2 illustrates that racemisation of the D-N-benzylidene amino add amide is fadle and can be carried out under very mild reaction conditions. After removal of die benzaldehyde die D,L-amino add amide can be recyded 100% conversion to the L-amino add is theoretically possible. Another method for racemisation and recycling of the L-amino add (path B, Figure A8.2) comprises the conversion of the L-amino add into die ester in the presence of concentrated add, followed by addition of ammonia, resulting in the formation of the amide. Addition of benzaldehyde and racemisation by OH- (pH =13) gives the D,L-amino add amide. In this way 100% conversion to die D-amino add is possible. [Pg.279]

In general, an ethyl(monoalkoxy)zinc is formed with amino alcohols6. Therefore, in the presence of an equimolar amount of chiral amino alcohol, a slow reduction of benzaldehyde to benzyl alcohol is observed rather than alkylation1. Alkylation only occurs with a ratio of diethylzinc to amino alcohol greater than equimolar. Consequently, a two-zinc species is postulated to be the actual catalyst1, n. [Pg.166]

With the stcrically constrained /(-amino alcohols N-P asymmetric amplification phenomena were observed similar to the effects found with 3-e.Y0-(dimethylamino)isoborneol (vide supra). Thus, alkylation of benzaldehyde with diethylzinc, catalyzed by a partially resolved catalyst N-P, gives 1-phenyl-1-propanol with an enantiomeric excess, which impressively exceeds the optical purity of the catalyst employed12. [Pg.168]

Polymer-supported amino alcohols and quaternary ammonium salts catalyze the enan-tioselective addition of dialkylzinc reagents to aldehydes (Table 31). When the quaternary ammonium salt F is used in hexane, it is in the solid state, and it catalyzes the alkylation of benzaldehyde with diethylzinc in good chemical yield and moderate enantioselectivity. On the other hand, when a mixture of dimethylformamide and hexane is used as solvent, the ammonium salt is soluble and no enantioselectivity is observed21. [Pg.174]

An interesting case of product-controlled simple diastereoselectivity has been reported103. [l-[Methyl(nitrosoamino)]-2-propenyl]lithium adds to benzaldehyde at — 78°C to give the amino alcohol with an anti/syn ratio of 65 35, but equilibration of the reversible reaction at room temperature leads exclusively to the more stable, vv -product. [Pg.242]

In order to overcome the poor electrophilicity ofimines, nitrones arc used as partners for reaction with iron acyl enolates 428. Benzaldehyde phenylnitrone (5) reacts rapidly with the aluminum-based enolate at —78 C to give a crude /J-hydroxyamino iron acyl 6 (68% yield). Treatment with aqueous titanium trichloride in tetrahydrofuran at room temperature causes a selective reduction of the N—O bond and affords the /1-amino iron acyl 7 with inverse configuration compared to the addition ofimines (99% yield d.r. 11 23). [Pg.767]

Miscellaneous Identified Inhibitors. 3-Acetyl-6-methoxy-benzaldehyde is present in the leaves of the desert shrub Encelia farinosa. It is apparently leached from the leaves and washed into the soil by rain. Concentrations of approximately 0.5 mg. per gram of dried leaf material have been measured. In sand culture studies, growth of tomato seedlings was inhibited by 50 p.p.m. while 115 p.p.m. reduced growth by 50% (53). A concentration of 250 p.p.m. killed the test plants within one day. The structure was confirmed by synthesis, and the synthetic material was shown to be as active as the natural product (54). Derivatives were also prepared in which a cyano, nitro, or amino group was substituted for the aldehyde moiety. The amino derivative was reported to be the most highly toxic. [Pg.132]

Auch aus Pentafluor-benzaldehyd oder -benzamid bzw. Pentafluor-4-ehlor- (bzw. -amino- oder -methoxy)-benzoesaure werden bevorzugt die entspreehenden Benzylalko-hole II und III erhalten4. [Pg.616]


See other pages where Benzaldehyde, 4-Amino is mentioned: [Pg.85]    [Pg.6]    [Pg.4]    [Pg.49]    [Pg.48]    [Pg.85]    [Pg.108]    [Pg.166]    [Pg.534]    [Pg.814]    [Pg.416]    [Pg.128]    [Pg.41]    [Pg.15]    [Pg.164]    [Pg.164]    [Pg.166]    [Pg.175]    [Pg.791]    [Pg.89]    [Pg.89]    [Pg.616]    [Pg.478]   


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