Cooperative behavior, simplest models

The simplest models of this cooperative behavior suppose that each monomeric unit along the chain has one of two possible states, H (helix) or C (coil). Fhe chain conformations are represented as one-dimensional sequences of H and C units. An example conformation is HHCCCCCHCHHHHC. 

The Hill equation is a three-parameter function k, n, Vniax), and constitutes the simplest equation that describes the kinetic behavior of cooperative enzymes. From a practical point of view, the next most useful model is the syimnetiy model. Even though it only accounts for positive cooperativity and is based on somewhat arbitrary assumptions, this model can account for aUosteric effects. 

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