Barnacles inhibition

Styloguanidins, e.g. 135, chitinase inhibitors from the marine sponge Stylotella aurantium, inhibit the moulting of cyprid larvae of barnacles at a concentration of 10 ppm [108]. They are closely related to palauamine (67). 

The bromotyramine derivatives ceratinamide A (136) and psammaplysin A (137) from the sponge Pseudoceratina purpurea inhibit the settlement and metamorphosis of cyprid larvae of the barnacle Balanus amphitrite (ED50 0.10 and 0.27 (Jg/ml). Interestingly, psammaplysin A induces larval metamorphosis of the ascidian Halocynthia roretzi (ED 0o 1.2 (Jg/ml) [74]. 

Matsumura, K., Mori, S., Nagano, M., and Fusetani, N., Lentil lectin inhibits adult extract-induced settlement of the barnacle Balanus amphitrite, J. Exp. Zool., 280, 213, 1998. 

Maki, J. S., Rittschof, D., Costlow, J. D., and Mitchell, R., Inhibition of attachment of larval barnacles, Balanus amphitrite, by bacterial surface films, Mar. Biol., 97, 199, 1988. 

Standing, J., Hooper, I.R., and Costlow, J.D., Inhibition and induction of barnacle settlement by natural products present in octocorals,./. Chem. Ecol., 10, 823, 1984. 

Rittschof, D., Hooper, I. R., and Costlow, J. D., Settlement inhibition of marine invertebrate larvae comparison of sensitivities of bryozoan and barnacle larvae, in Marine Biodeterioration, Thompson, M., Sarojini, R., and Nagabhushanam, R., Eds., Oxford IBW Publishing Co., Bombay, 1988, 599. 

Two syntheses of pseudoceratidine (120), which was reported to inhibit metamorphosis of the barnacle Balanus amphitrite, have been described [146,147]. To delineate the structural requirements for this bioactivity, the corresponding N-1 and N-8 mono-(4,5-dibromo-2-pyrrolyl) amides of spermidine were also synthesized, as well as the closely related mono- and bis-(4,5-dibromo-2-pyrrolecarboxamido) residues to test the importance of the pyrrole substituents and the positively charged secondary amine group in 120 [148]. 

Colchicine-like mitosis in onion root tip Narcosis of barnacle larvae Narcosis of 2.5-day tadpoles Narcosis of 12-day tadpoles I5o guinea pig ileum 100% inhibition tadpole movement Narcosis of 83-day tadpoles... 

This notion was supported by additional studies in which platelet water was totally exchanged with deuterium oxide (D2O) (29). D2O had been previously shown to block the release of Ca2 from the sarcoplasmic reticulum of barnacle muscle and inhibit muscular contraction (30). Since the... 

Kalihinol A (108) was originally isolated as an antimicrobial compound from Acanthella sp. collected in Guam. Kalihinol A, and other isocyanides, including kalihinenes X (166), Y (167), and Z (168), as well as 10-formamidokalihinene (169) — all of which were isolated from the Japanese Acanthella cavernosa—were shown to inhibit the larval settiement and metamorphosis at concentrations less than 0.1 pgmP whereas toxicity toward the barnacle cyprids was very low (LD50 values > lOOpgmP ). Antimalarial activity was also reported for other biological activities of kalihinol A. ... 

Kem WR, Soti F, Rittschof D. Inhibition of barnacle larval settlement and crustacean toxicity of some hoplonemetrine pyridil alkaloids. Biomol Eng 2003 20(4-6) 355-61, SI. 

Guy SP, Jones D, Mann DMA, Itzhaki RF (1991) Human neuroblastoma cells treated with aluminium express, an epitope associated with Alzheimer s disease neurofibrillary tangles. Neurosci Lett 121 166-168 Hollosi M, Urge L, Perczel A, Kajtar J, Teplan I, Otvos L Jr, Fasman GD (1992) Metal ion-induced conformational changes of phosphorylated fragments of human neurofilament (NF-M) protein. J Mol Biol 223 673-682 Huang Y-P, Bittar EE (1991) Protection by GTP from the effects of aluminum on the sodium efflux in barnacle muscle fibers. Biochim Biophys Acta 1062 255-263 Huber CT, Frieden E (1970) The inhibition of ferroxidase by trivalent and other metal ions. J Biol Chem 245 3979-3984... 

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