Baltimore Longitudinal Study of Aging

Kawas C, Resnick S, Morrison A, Brookmeyer R, Corrada M, Zonderman A, Bacal C, Lingle DD, Metter E. (1997). A prospective study of estrogen replacement therapy and the risk of developing Alzheimer s disease the Baltimore longitudinal study of aging. Neurology. 48(6) 1517-21. 

Harman SM et al Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2001 86 724. [PMID 11158037]... 

Yasar, S., Corrada, M., Brookmeyer, R., and Kawas, C. (2005). Calcium channel blockers and risk of AD the Baltimore Longitudinal Study of Aging. Neurobiol Aging 26, 157-163. 

Kawas C, Gray S, Brookmeyer R, Fozard J, Zonderman A. Age-specific incidence rates of Alzheimer s disease The Baltimore Longitudinal Study of Aging. Neurology 2000 54(1l) 2072-2077. 

Baltimore Longitudinal Study of Aging Male Humans... 

Korrapati MR, Sorkin JD, Andres R, et al. Acetylator phenotype in relation to age and gender in the Baltimore Longitudinal Study of Aging. J CUn Pharmacol 1997 37 83-91. 

The peak incidence of clinical BPH occurs at 63 to 65 years of age. Symptomatic disease is uncommon in men younger than 50 years of age, but some urinary voiding symptoms are present by the time men turn 60 years of age. The Boston Area Normative Aging Study estimated that the cumulative incidence of clinical BPH was 78% in patients at age 80 years. Similarly, the Baltimore Longitudinal Study of Aging projected that approximately 60% of men of at least 60 years of age develop clinical BPH. ... 

In the Health Professional Follow-Up Study (Rimm et al.y 1993) vitamin C intake could not be related to CHD morbidity however, a significant inverse relationship was found with vitamin E. In a study in Finland with about 5000 men and women, dietary intake of vitamin C was inversely related to coronary mortality only among women. In this study, vitamin E intake was inversely related to coronary mortality in both men and women. A substudy of the Baltimore Longitudinal Study of Aging with 827 participants showed that high levels of vitamin C were associated with less atherogenetic lipid profiles (Hallfrisch et al., 1994). 

Bell, D.S. and O Keefe, J.H. 2007. White cell count, mortality, and metabolic syndrome in the Baltimore longitudinal study of aging. J Am.Coll.Cardiol. 50 1810-1811. 

Harik-Khan, R.I., Wise, R.A. Fozard, XL. 1998. Determinants of maximal inspiratory pressure. The Baltimore Longitudinal Study of Aging. Am J Respir Crit Care Med, 158, 1459 4. 

Cross-sectional studies demonstrate decreased GFR as a function of age when GFR is measured as inulin, iothalamate, or creatinine clearance. The Baltimore Longitudinal Study on Aging, an evaluation of 254 normal healthy subjects, revealed that creatinine clearance decreases at the rate of approximately 0.75 mL/min per 1.73 m per year beginning at the fourth decade of life. These subjects were evaluated prospectively for up to 23 years. Interestingly, approximately one-third of the subjects showed no change in renal function from their baseline value, and a small number showed an increased clearance. These changes may be due to normal physio-... 

Prospective cohort studies were not able to relate vitamin C with lens opacities. In the Baltimore Longitudinal Study on Aging, plasma ascorbic acid was not inversely associated with risk, but vitamin E was (Vitale et al., 1993). In the Women s Health Study and the Physicians Health Study of Harvard University, Boston, vitamin C intake did not show a meaningful relationship to risk (Hankinson et al., 1992 Seddon et al., 1994). A modest reduction in risk was found with multivitamin use in men. Also the Italian-American Cataract Study Group (1991) did not find a significant reduction in risk for any nutrient studied, including vitamin C. 

AMD was not inversely related to consumption of fruits and vegetables rich in vitamin C, but rather to those rich in vitamin A, in a cross-sectional survey (Goldberg et al., 1988). West et al. (1994) show, for the participants of the Baltimore Longitudinal Study on Aging, that a high concentration of vitamin E but not of vitamin C or P-carotene, in serum reduces the risk for AMD. The Eye Disease Case-Control Study (1993) found a protective effect with high plasma P-carotene, but not with high vitamin C levels. 

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