Metabolite bioactive, from bacteria

Abstract Diverse arrays of new bioactive secondary metabolites have been isolated from marine microorganisms and the number of publications in this area has greatly increased in recent years. In this review, the emphasis is placed on new compounds with antitumor, enzyme inhibitors, antivirus, and other bioactive metabolites from fungi, bacteria, actinomycetes, and cyanobacteria reported between 2000 and 2005. Supply is a major limitation in the development of marine bioproducts, and the methods for supplying these products are important. So in this review, the secondary major point is placed on the chemical synthetic studies. References of 390 structures and 263 citations are overall presented in this review. 

We have already isolated several new, bioactive compounds from these robust, acid mine waste bacteria and fungi, several of which will be described later in this chapter. Over the next few years we will continue the search for bioactive metabolites from these microbes. 

BIOACTIVE METABOLITES FROM PHYTOPATHOGENIC BACTERIA AND PLANTS... 

Bioactive metabolites from phytopathogenic bacteria and plants 581... 

This review describes bioactive compounds isolated from marine algae and invertebrates with an emphasis on then-uniqueness. Because of limited space, metabolites from bacteria, cyanobacteria, and fungi cannot be included, although some from cyanobacterial and endosymbiotic bacterial origins are described (some reviews on metabolites of marine bacteria, cyanobacteria, and fungi are provided in the Further Reading section). Structures and bioactivities are described for compounds that represent natural product classes, but steroids and carotenoids are not included. 

Shaaban M (2004) Bioactive secondary metabolites from marine and terrestrial bacteria isoquinolinequinones, bacterial compoimds with a novel pharmacophor. PhD thesis, University of Gottingen... 

Keywords. New bacteria from the North Sea, Secondary metabolites. Bioactivity, Biotechnological production. Structure elucidation. Phylogenetic screening... 

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