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Tizanidine Baclofen

BETA-BLOCKERS SKELETAL-BACLOFEN, TIZANIDINE t hypotensive effect with baclofen ortizanidine. Risk of bradycardia with tizanidine Additive hypotensive effect. Tizanidine has a negative inotropic and chronotropic effect Monitor BP at least weekly until stable. Warn patients to report symptoms of hypotension (light-headedness, dizziness on standing, etc.)... [Pg.75]

BACLOFEN, TIZANIDINE 1. ANAESTHETICS - general 2. ANTICANCER AND IMMUNOMODULATING DRUGS - IL-2 3. ANTIDEPRESSANTS - MAOIs 4. ANTI HYPERTENSIVES AND HEART FAILURE DRUGS 5. ANTI-PSYCHOTICS 6. ANXIOLYTICS AND HYPNOTICS 7. BETA-BLOCKERS 8. CALCIUM CHANNEL BLOCKERS 9. DIURETICS 10. NITRATES 11. PERIPHERAL VASODILATORS-moxisylyte (thymoxamine) 12. POTASSIUM CHANNEL ACTIVATORS t hypotensive effect Additive hypotensive effect. Tizanidine also has a negative chronotropic effect and may cause additive bradycardia with beta-blockers and calcium channel blockers Monitor BP at least weekly until stable. Warn patients to report symptoms of hypotension (light-headedness, dizziness on standing, etc.)... [Pg.489]

BACLOFEN, TIZANIDINE ANAESTHETICS - GENERAL t hypotensive effect Additive hypotensive effect. Tizanidine also has a negative chronotropic effect and may cause additive bradycardia with beta-blockers and calcium channel blockers Monitor BP closely, especially during induction of anaesthesia... [Pg.489]

Toxicity The sedation produced by diazepam is significant but milder than that produced by other sedative-hypnotic drugs at doses that induce equivalent muscle relaxation. Baclofen produces less sedation than diazepam. Dantrolene causes significant muscle weakness but less sedation than either diazepam or baclofen. Tizanidine may cause drowsiness and hypotension. [Pg.248]

CALCIUM CHANNEL BLOCKERS 9. DIURETICS 10. MUSCLE RELAXANTS-baclofen, tizanidine... [Pg.212]

DIURETICS 10. MUSCLE RELAXANTS - baclofen, tizanidine 11. NITRATES... [Pg.214]

Clinical trials with oral tizanidine report comparable efficacy in relieving muscle spasm to diazepam, baclofen, and dantrolene. However, tizanidine produces a different spectrum of adverse effects, including drowsiness, hypotension, dry mouth, and asthenia. The dosage requirements vary markedly among patients, and individual dosage titration is necessary to achieve an optimal clinical effect. [Pg.593]

Groves L, Shellenberger MK, Davis CS Tizanidine treatment of spasticity A meta-analysis of controlled, double-blind, comparative studies with baclofen and diazepam. Adv Ther 1998 15 241. [PMID 10186943]... [Pg.599]

The three agents traditionally used in the treatment of spasticity are baclofen, diazepam, and dantrolene sodium (see Table 13-3, Fig. 13-2). Two newer agents, gabapentin and tizanidine, are also available for treating spasticity in various conditions. All of these agents are addressed below. [Pg.166]

Tizanidine [Zanaflex] Adult 8 mg every 6-8 hours as needed. Children The safety and effficacy of this drug in treating spasticity in children have not been established. May reduce a in spinal cord disorders while producing fewer side effects and less generalized muscle weakness than other agents (oral baclofen, diazepam]. [Pg.167]

Adverse Effects. The most common side effects associated with tizanidine include sedation, dizziness, and dry mouth.40 As indicated, however, tizanidine tends to have a more favorable side effect profile than other alpha-2 agonists, and this drug produces less generalized weakness than oral baclofen or diazepam. Tizanidine may therefore be a better alternative to these other agents in patients who need to reduce spasticity while maintaining adequate muscle strength for ambulation, transfers, and so forth. [Pg.171]

BZDs BACLOFEN, METHOCARBAMOL, TIZANIDINE t sedation Additive effect Warn patients... [Pg.269]

BACLOFEN, METHOCARBAMOL, TIZANIDINE ALCOHOL t sedation Additive effect Warn patients advise them to drink alcohol only in moderation and not to drive if they have drunk any alcohol and are taking these muscle relaxants... [Pg.489]

Spasticity results from lesions at various sites within the central nervous system and spinal cord. Drugs used include the GABA agonist baclofen, diazepam and tizanidine (an Oj-adrenoceptor agonist). [Pg.429]

Stien R, Nordal HJ, Oftedal SI, Slettebo M. The treatment of spasticity in mrrltiple sclerosis a double-blind clinical trial of a new anti-spastic drug tizanidine compared with baclofen. Acta Neurol Scand 1987 75(3) 190-4. [Pg.3437]

Dantrolene has a direct action on skeletal muscle to cause relaxation baclofen inhibits transmission at the spinal cord by acting on inhibitory presynaptic gamma-aminobutyric acid B (GABAb) receptors benzodiazepines cause muscle relaxation by some central action and tizanidine is an a2 adrenoreceptor agonist presumably with a central action. [Pg.131]

Side effects of dantrolene, baclofen and tizanidine are similar, being motor incoordination, drowsiness, dizziness, weakness, fatigue and gastrointestinal disturbances. [Pg.131]

See other pages where Tizanidine Baclofen is mentioned: [Pg.130]    [Pg.135]    [Pg.137]    [Pg.489]    [Pg.207]    [Pg.566]    [Pg.566]    [Pg.566]    [Pg.1250]    [Pg.130]    [Pg.135]    [Pg.137]    [Pg.489]    [Pg.207]    [Pg.566]    [Pg.566]    [Pg.566]    [Pg.1250]    [Pg.182]    [Pg.171]    [Pg.175]    [Pg.176]    [Pg.630]    [Pg.109]    [Pg.572]    [Pg.572]    [Pg.1016]    [Pg.99]    [Pg.347]   
See also in sourсe #XX -- [ Pg.1250 ]



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